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Review
. 2021 Jul;31(4):e2197.
doi: 10.1002/rmv.2197. Epub 2020 Nov 22.

Full-length genome sequencing of RNA viruses-How the approach can enlighten us on hepatitis C and hepatitis E viruses

Elodie Laugel  1   2   3 , Cédric Hartard  1   2   3 , Hélène Jeulin  1   2   3 , Sibel Berger  2 , Véronique Venard  1   2 , Jean-Pierre Bronowicki  1   4 , Evelyne Schvoerer  1   2   3
Affiliations
Review

Full-length genome sequencing of RNA viruses-How the approach can enlighten us on hepatitis C and hepatitis E viruses

Elodie Laugel et al. Rev Med Virol. 2021 Jul.

Abstract

Among the five main viruses responsible for human hepatitis, hepatitis C virus (HCV) and hepatitis E virus (HEV) are different while sharing similarities. Both viruses can be transmitted by blood or derivatives whereas HEV can also follow environmental or zoonotic routes. These highly variable RNA viruses can cause chronic hepatitis potentially leading to hepatocarcinoma. HCV and HEV can develop new structures and functions under selective pressure to adapt to host immunity, human tissues, treatments or even various animal reservoirs. Elsewhere, with directly acting antiviral treatments, HCV can be eradicated whereas HEV is an emerging pathogen against which specific treatments have to be improved. As a unique molecular tool able to explore viral genomic plasticity, full-length genome (FLG) sequencing has become easier, faster and cheaper. The present review will show how FLG sequencing can explore these RNA viruses with the aim to investigate key genomics data to improve basic knowledge, patients' healthcare and preventive tools.

Keywords: RNA viruses; full-length genome; hepatitis C virus; hepatitis E virus.

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References

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