Aged vasculature drives neutrophils mad

Marco Di Gioia¹, Ivan Zanoni²

Affiliations

¹ Harvard Medical School and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA, USA.
² Harvard Medical School and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA, USA. Electronic address: ivan.zanoni@childrens.harvard.edu.

PMID: 34260883
DOI: 10.1016/j.immuni.2021.06.010

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Aged vasculature drives neutrophils mad

Marco Di Gioia et al. Immunity. 2021.

Free article

. 2021 Jul 13;54(7):1369-1371.

doi: 10.1016/j.immuni.2021.06.010.

Authors

Marco Di Gioia¹, Ivan Zanoni²

Affiliations

¹ Harvard Medical School and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA, USA.
² Harvard Medical School and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA, USA. Electronic address: ivan.zanoni@childrens.harvard.edu.

PMID: 34260883
DOI: 10.1016/j.immuni.2021.06.010

Abstract

Inflammaging drives age-related pathologies. In this issue of Immunity, Barkaway et al. illustrate how aged endothelial cells and mast cells promote reverse migration of neutrophils from inflamed tissue back into circulation, causing tissue damage at distal sites.

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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage.
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Barkaway A, et al. Immunity. 2021 Jul 13;54(7):1494-1510.e7. doi: 10.1016/j.immuni.2021.04.025. Epub 2021 May 24. Immunity. 2021. PMID: 34033752 Free PMC article.

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Aged vasculature drives neutrophils mad

Affiliations

Aged vasculature drives neutrophils mad

Authors

Affiliations

Abstract

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