Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

doi:10.1038/s41392-021-00689-y

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. 2021 Jul 14;6(1):267.

doi: 10.1038/s41392-021-00689-y.

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

Cameron Mura^#¹, Saskia Preissner^#², Susanne Nahles³, Max Heiland³, Philip E Bourne⁴, Robert Preissner⁵

Affiliations

¹ School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. cmura@virginia.edu.
² Department Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Saskia.Preissner@charite.de.
³ Department Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁴ School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
⁵ Institute of Physiology and Science-IT, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

^# Contributed equally.

PMID: 34262013
PMCID: PMC8278809
DOI: 10.1038/s41392-021-00689-y

Comment

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

Cameron Mura et al. Signal Transduct Target Ther. 2021.

. 2021 Jul 14;6(1):267.

doi: 10.1038/s41392-021-00689-y.

Authors

Cameron Mura^#¹, Saskia Preissner^#², Susanne Nahles³, Max Heiland³, Philip E Bourne⁴, Robert Preissner⁵

Affiliations

¹ School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. cmura@virginia.edu.
² Department Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Saskia.Preissner@charite.de.
³ Department Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁴ School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
⁵ Institute of Physiology and Science-IT, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

^# Contributed equally.

PMID: 34262013
PMCID: PMC8278809
DOI: 10.1038/s41392-021-00689-y

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Kaplan–Meier survival curves are shown for COVID-19 patients with (blue) or without (red) the dual combination treatment of famotidine and aspirin; the time-evolution of survival probabilities is given in terms of number of days after the index event (a positive COVID-19 diagnosis)

See this image and copyright information in PMC

Comment on

Histamine receptors and COVID-19.
Ennis M, Tiligada K. Ennis M, et al. Inflamm Res. 2021 Jan;70(1):67-75. doi: 10.1007/s00011-020-01422-1. Epub 2020 Nov 18. Inflamm Res. 2021. PMID: 33206207 Free PMC article.

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References

1. Ennis M, Tiligada K. Histamine receptors and COVID-19. Inflamm. Res. 2021;70:67–75. doi: 10.1007/s00011-020-01422-1. - DOI - PMC - PubMed
1. Freedberg DE, et al. Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: a propensity score matched retrospective cohort study. Gastroenterology. 2020;159:1129–1131 e1123. doi: 10.1053/j.gastro.2020.05.053. - DOI - PMC - PubMed
1. Mura, C., Preissner, S., Preissner, R. & Bourne, P. E. A birds-eye (Re)view of acid-suppression drugs, COVID-19, and the highly variable literature. Preprint at https://arxiv.org/abs/2104.12003 (2021). - PMC - PubMed
1. Hogan II RB, et al. Dual-histamine receptor blockade with cetirizine-famotidine reduces pulmonary symptoms in COVID-19 patients. Pulm. Pharm. Ther. 2020;63:101942. doi: 10.1016/j.pupt.2020.101942. - DOI - PMC - PubMed
1. Loucera C, et al. Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection. Signal Transduct. Target Ther. 2020;5:290. doi: 10.1038/s41392-020-00417-y. - DOI - PMC - PubMed

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[1] Ennis M, Tiligada K. Histamine receptors and COVID-19. Inflamm. Res. 2021;70:67–75. doi: 10.1007/s00011-020-01422-1. - DOI - PMC - PubMed

[2] Ennis M, Tiligada K. Histamine receptors and COVID-19. Inflamm. Res. 2021;70:67–75. doi: 10.1007/s00011-020-01422-1. - DOI - PMC - PubMed

[3] Freedberg DE, et al. Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: a propensity score matched retrospective cohort study. Gastroenterology. 2020;159:1129–1131 e1123. doi: 10.1053/j.gastro.2020.05.053. - DOI - PMC - PubMed

[4] Freedberg DE, et al. Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: a propensity score matched retrospective cohort study. Gastroenterology. 2020;159:1129–1131 e1123. doi: 10.1053/j.gastro.2020.05.053. - DOI - PMC - PubMed

[5] Mura, C., Preissner, S., Preissner, R. & Bourne, P. E. A birds-eye (Re)view of acid-suppression drugs, COVID-19, and the highly variable literature. Preprint at https://arxiv.org/abs/2104.12003 (2021). - PMC - PubMed

[6] Mura, C., Preissner, S., Preissner, R. & Bourne, P. E. A birds-eye (Re)view of acid-suppression drugs, COVID-19, and the highly variable literature. Preprint at https://arxiv.org/abs/2104.12003 (2021). - PMC - PubMed

[7] Hogan II RB, et al. Dual-histamine receptor blockade with cetirizine-famotidine reduces pulmonary symptoms in COVID-19 patients. Pulm. Pharm. Ther. 2020;63:101942. doi: 10.1016/j.pupt.2020.101942. - DOI - PMC - PubMed

[8] Hogan II RB, et al. Dual-histamine receptor blockade with cetirizine-famotidine reduces pulmonary symptoms in COVID-19 patients. Pulm. Pharm. Ther. 2020;63:101942. doi: 10.1016/j.pupt.2020.101942. - DOI - PMC - PubMed

[9] Loucera C, et al. Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection. Signal Transduct. Target Ther. 2020;5:290. doi: 10.1038/s41392-020-00417-y. - DOI - PMC - PubMed

[10] Loucera C, et al. Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection. Signal Transduct. Target Ther. 2020;5:290. doi: 10.1038/s41392-020-00417-y. - DOI - PMC - PubMed

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Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

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Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

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