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Review
. 2021 Jul 6:10:225-236.
doi: 10.2147/ITT.S288546. eCollection 2021.

Targeting CD22 for the Treatment of B-Cell Malignancies

Nikesh N Shah  1 , Lubomir Sokol  2
Affiliations
Review

Targeting CD22 for the Treatment of B-Cell Malignancies

Nikesh N Shah et al. Immunotargets Ther. .

Abstract

Immunotherapeutic agents play an increasingly important role in the treatment of B-cell malignancies. CD19 and CD20 are common targets for lymphoid malignancies, though patients who relapse have few therapeutic options remaining. CD22 is a cell surface sialoglycoprotein uniquely present on B-cells and regulates B-cell function and proliferation. Thus, it is an appealing therapeutic target for autoimmune disorders and B-cell malignancies. A variety of therapies targeting CD22 have been developed, including monoclonal antibodies, antibody-drug conjugates, radioimmunoconjugates, chimeric antigen receptor T cells, and bispecific antibodies. Here, we review the biology of CD22 and key therapies targeting CD22 in lymphoid malignancies.

Keywords: CD22; acute lymphoblastic leukemia; bispecific antibody; chimeric antigen receptor; epratuzumab; inotuzumab ozogamicin; lymphoma.

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Conflict of interest statement

The authors reported no conflicts of interest for this work.

Figures

Figure 1
Figure 1
Legend: Simplified schema depicting current therapies targeting CD22 in B-cell malignancies. (A) Naked antibody; (B) Antibody-drug conjugate; (C) Radioimmunoconjugate; (D) Bispecific antibody/bispecific T-cell engager; (E) Chimeric antigen receptor (CAR)-T cell; (F) Bispecific CAR-T cell; (G) Tandem bispecific CAR-T cell. Abbreviations: 90Y, Yttrium-90. Figure created with BioRender.com.
See this image and copyright information in PMC

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