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. 2021 Jul 4;5(5):e12564.
doi: 10.1002/rth2.12564. eCollection 2021 Jul.

A tail of two ITAMs: GPVI/FcRγ and FcγRIIa's role in platelet activation and thrombus stability

Keith B Neeves  1
Affiliations

A tail of two ITAMs: GPVI/FcRγ and FcγRIIa's role in platelet activation and thrombus stability

Keith B Neeves. Res Pract Thromb Haemost. .
No abstract available

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Figures

FIGURE 1
FIGURE 1
Potential signaling pathways for fibrinogen‐mediated platelet activation. Fibrinogen can bind to glycoprotein VI (GPVI) and the integrin αIIbβ3. Fibrinogen binding results in phosphorylation of Src family kinases (Src) and spleen tyrosine kinase (Syk) associated with FcRγ and FcγRIIa. Integrins can also signal through Syk in the absence of ITAMs. Syk activated phospholipase Cγ2 (PLCγ2), leading to calcium release from intracellular stores. Created with BioRender.com
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