Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;41(1):127-132.
doi: 10.1007/s10096-021-04290-7. Epub 2021 Jul 15.

Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital

Konstantina Chrysou  1 , Olympia Zarkotou  2 , Sofia Kalofolia  3 , Panagiota Papagiannakopoulou  2 , Vasiliki Mamali  2 , Georgios Chrysos  4 , Katina Themeli-Digalaki  2 , Nikolaos Sypsas  5 , Athanasios Tsakris  1 , Spyros Pournaras  6   7
Affiliations

Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital

Konstantina Chrysou et al. Eur J Clin Microbiol Infect Dis. 2022 Jan.

Abstract

This study aimed to investigate the effects of a 4-year antibiotic stewardship program (ASP) in a tertiary hospital. We monitored data for 2015 (pre-intervention) and 2016-2019 (post-intervention) about antibiotic consumption (DDD/100 bed days), Clostridioides difficile infections (CDIs), resistance rates, length of stay (LOS), and annual antibiotic costs. Significant reductions were observed for total antibiotics/colistin/carbapenems/quinolones/tigecycline consumption and resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and vancomycin-resistant enterococci. Considerable reductions occurred for LOS (4.18 [2015]/3.0 [2019] days), CDIs (1.47 [2015]/0.86 [2019] per 1000 patients), antibiotic cost/patient (39.45€ [2015]/23.69€ [2019]). The ASP was successful in reducing antibiotic consumption, antibiotic costs, length of hospital stay, and CDIs.

Keywords: Antibiotic consumption; Antibiotic costs; Antimicrobial stewardship; Clostridioides difficile infections; Length of hospital stay.

PubMed Disclaimer

References

    1. European Centre for Disease Control (ECDC). SURVEILLANCE REPORT Antimicrobial consumption in the EU/EEA Annual epidemiological report for 2018. https://www.ecdc.europa.eu/sites/default/files/documents/Antimicrobial-c...
    1. Barlam TF, Cosgrove SE, Abbo LM et al (2016) Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 62:e51-77 - DOI
    1. Huttner A, Harbarth S, Carlet J et al (2013) Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum. Antimicrob Resist Infect Control 2:31 - DOI
    1. Nowak MA, Nelson RE, Breidenbach JL et al (2012) Clinical and economic outcomes of a prospective antimicrobial stewardship program. Am J Health Syst Pharm 69:1500–1508 - DOI
    1. Davey P, Marwick CA, Scott CL et al (2017) Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2:CD003543 - PubMed

MeSH terms

Substances

LinkOut - more resources