Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb;25(2):159-164.
doi: 10.1038/s41391-021-00413-5. Epub 2021 Jul 15.

The microbiome and prostate cancer

Juan Javier-DesLoges  1 , Rana R McKay  2   3 , Austin D Swafford  4 , Gregory D Sepich-Poore  4 , Rob Knight  4 , J Kellogg Parsons  5
Affiliations
Review

The microbiome and prostate cancer

Juan Javier-DesLoges et al. Prostate Cancer Prostatic Dis. 2022 Feb.

Abstract

There is growing evidence that the microbiome is involved in development and treatment of many human diseases, including prostate cancer. There are several potential pathways for microbiome-based mechanisms for the development of prostate cancer: direct impacts of microbes or microbial products in the prostate or the urine, and indirect impacts from microbes or microbial products in the gastrointestinal tract. Unique microbial signatures have been identified within the stool, oral cavity, tissue, urine, and blood of prostate cancer patients, but studies vary in their findings. Recent studies describe potential diagnostic and therapeutic applications of the microbiome, but further clinical investigation is needed. In this review, we explore the existing literature on the discovery of the human microbiome and its relationship to prostate cancer.

PubMed Disclaimer

Conflict of interest statement

Juan Javier-DesLoges, MD, MS – No Conflict of Interest

Rana R. McKay, MD- No Conflict of Interest

Austin D. Swafford, PhD. - No Conflict of Interest

Gregory D. Sepich-Poore, B.S.E. - No Conflict of Interest

Rob Knight, PhD. - No Conflict of Interest

J. Kellogg Parsons MD, MHS - No Conflict of Interest

Figures

Figure 1:
Figure 1:
Article Selection Flow Diagram
See this image and copyright information in PMC

References

    1. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59–65. - PMC - PubMed
    1. Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol 2016; 14: e1002533. - PMC - PubMed
    1. Wheeler KM, Liss MA. The Microbiome and Prostate Cancer Risk. Curr Urol Rep 2019; 20: 66. - PubMed
    1. Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet 2012; 13: 260–270. - PMC - PubMed
    1. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell 2014; 157: 121–141. - PMC - PubMed