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. 2019 Feb 1;27(1):63-78.
doi: 10.26650/FNJN346677. eCollection 2019 Feb.

[Is There an Effect of Dietary Fructose on Development and Prognosis of Chronic Diseases?]

[Article in Turkish]
Armağan Aytuğ Yürük  1 , Reyhan Nergiz-Ünal  1
Affiliations

[Is There an Effect of Dietary Fructose on Development and Prognosis of Chronic Diseases?]

[Article in Turkish]
Armağan Aytuğ Yürük et al. Florence Nightingale Hemsire Derg. .

Abstract
in English, Turkish

Dietary sources of fructose are not only honey, fruit, sucrose, but also high fructose corn syrup in various foods and beverages. Total amount of daily fructose intake is rising by especially increasing use of high fructose corn syrup in the food industry. Fructose can lead to obesity by contributing to high-energy intake and lipogenesis in the body. Depending on the source of fructose, dose and duration, it was involved in de-novo lipid synthesis. Fructose may increase the risk of insulin resistance, non-alcoholic fatty liver and kidney diseases by affecting blood glucose and insulin levels. On the other hand, fructose may initiate inflammatory processes in the organism. In addition to these, fat or salt consisting typical western type diet with high fructose consumption, can increase the potential effect of fructose on chronic diseases. As a result, although it is not fully supported by clinical studies, it is thought that high amounts of fructose intake may increase the risk of chronic disease shown by experimental studies. Also it should be noted that beside high fructose, typical western-style high-fat and high-salt diet may increase the risk of chronic diseases such as obesity, cardiovascular diseases and worsen metabolic syndrome parameters. Furthermore, synthetic fructose, is able to cause some adverse metabolic effects when taken in large amounts; consumption of high amounts of fructose by fruit or honey these negative effects can be either not seen or less observed based on the amount.

Diyetteki fruktozun kaynakları bal, meyve ve sükrozun yanı sıra yüksek fruktozlu nişasta bazlı şeker ile tatlandırılmış çeşitli yiyecek ve içeceklerdir. Fruktoz; diyetle alınan toplam enerji miktarı ile lipogenezi arttırarak obeziteye yol açabilmektedir. Alım dozu, süresi ve fruktozun kaynağına bağlı olarak, alınan fruktozun çoğu metabolize edilerek de novo lipit sentezine katılabilmektedir. Kan glikoz ve insülin seviyelerini etkileyerek insülin direnci oluşumu, non-alkolik karaciğer yağlanması ve böbrek hastalıkları riskini de arttırabilmektedir. Ayrıca yüksek fruktoz tüketimi organizmadaki inflamatuar süreçleri başlatabilmektedir. Öte yandan tipik batı tarzı diyette yüksek fruktozla birlikte yüksek yağlı veya tuzlu beslenme fruktozun kronik hastalıklar üzerindeki bu olası etkilerini arttırabilmektedir. Sonuç olarak klinik çalışmalarla tam olarak desteklenmemiş olsa da deneysel çalışmaların sonuçlarına göre yüksek miktarda fruktoz alımının kronik hastalık riskini arttırabileceği düşünülmektedir. Ayrıca tipik batı tarzı yüksek yağlı, şekerli ve tuzlu diyetle birlikte fazla miktarda fruktoz tüketiminin obezite, kardiyovasküler hastalıklar gibi kronik hastalıkların riskini arttırabileceği ve metabolik sendrom parametrelerini daha fazla kötüleştirebileceği unutulmamalıdır. Ancak sentetik fruktoz, yüksek miktarda alındığında bazı olumsuz metabolik etkilere neden olabilse de kaynağı meyve ya da bal olan fruktozun yüksek miktarda tüketiminde bu olumsuz etkiler görülmemekte ya da tüketim miktarına bağlı olarak daha az oluşabilmektedir.

Keywords: Diabetes; cancer; cardio-vascular diseases; fructose; obesity.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

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