Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jan 12;38(1-2):51-72.
doi: 10.1007/BF01875162.

Effects of calcium ionophores on the transport and distribution of calcium in isolated cells and in liver and kidney slices

A B Borle, R Studer

Effects of calcium ionophores on the transport and distribution of calcium in isolated cells and in liver and kidney slices

A B Borle et al. J Membr Biol. .

Abstract

The effects of calcium ionophores on cellular calcium metabolism were studied in cultured kidney cells, in cells freshly isolated from rat kidney, and in liver and kidney slices. In isolated cells, these ionophores decreased the total cellular Ca content and the mitochondrial Ca. 45Ca efflux from prelabelled cells was also stimulated even in the absence of extracellular Ca. In slices, the ionphore A23187 increased the total slice Ca and the uptake of 45Ca. However, the mitochondria isolated from these slices treated with the ionophore had a lower total Ca and a depressed relative radioactivity. These results suggest that the increased cytosolic Ca produced by Ca ionophores may be due to mobilization of intracellular Ca stores rather than to a net shift of Ca from the extracellular fluids to the cell.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1974 Sep 23;60(2):542-8 - PubMed
    1. Arch Biochem Biophys. 1975 Mar;167(1):104-15 - PubMed
    1. J Biol Chem. 1975 Jun 25;250(12):4575-9 - PubMed
    1. Biochim Biophys Acta. 1973 Nov 2;329(1):98-107 - PubMed
    1. J Gen Physiol. 1970 Feb;55(2):163-86 - PubMed