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Editorial
. 2021 Nov 2;23(11):1814-1815.
doi: 10.1093/neuonc/noab179.

An early foray with targeted therapy and inspiring novel approaches to combat adult medulloblastoma

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Editorial

An early foray with targeted therapy and inspiring novel approaches to combat adult medulloblastoma

Helen A Shih. Neuro Oncol. .
No abstract available

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References

    1. Taylor MD, Northcott PA, Korshunov A, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123(4):465–472. - PMC - PubMed
    1. Northcott PA, Buchhalter I, Morrissy AS, et al. The whole-genome landscape of medulloblastoma subtypes. Nature. 2017;547(7663):311–317. - PMC - PubMed
    1. Frappaz D, Barritault M, Montane L, et al. MEVITEM: a phase I/II of vismodegib + temozolomide vs temozolomide in patients with recurrent/refractory medulloblastoma with sonic hedgehog pathway activation. Neuro Oncol. 2021;23(11):1949–1960. - PMC - PubMed
    1. Kool M, Jones DT, Jäger N, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014;25(3):393–405. - PMC - PubMed
    1. Li Y, Song Q, Day BW. Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis. Acta Neuropathol Commun. 2019;7(1):123. - PMC - PubMed