Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;157(1):110-114.
doi: 10.1002/ijgo.13830. Epub 2021 Aug 7.

Spontaneous versus morcellator-related benign metastasizing leiomyoma-A retrospective study

Tamar Perri  1 , Daphna Amitai Komem  2   3 , Sara Apter  3   4 , Yael Inbar  3   4 , Daniela Dick-Necula  3   5 , Gabriel Levin  1 , Jacob Korach  2   3
Affiliations

Spontaneous versus morcellator-related benign metastasizing leiomyoma-A retrospective study

Tamar Perri et al. Int J Gynaecol Obstet. 2022 Apr.

Abstract

Objective: To compare characteristics, disease course, and prognosis of spontaneous versus iatrogenic benign metastasizing leiomyoma (BML).

Methods: A retrospective cohort study comparing iatrogenic and spontaneous BML.

Results: Twenty cases were included, 12 (60%) spontaneous and 8 (40.0%) iatrogenic with a median follow up of 3.4 years. The rate of asymptomatic presentation did not differ between study groups (P = 0.157). When symptoms occurred, dyspnea was more common in the spontaneous group (66.6% vs 0%, P = 0.023) and self-palpation was more common in the iatrogenic group (57.1% vs 0%, P = 0.023). Intravascular masses were more common in the spontaneous group (66.6% vs 0%, P = 0.029). Rate of BML located in abdominal/pelvic cavity was higher in the iatrogenic group (100.0% vs 41.6%, P = 0.014). Of the 12 women in the spontaneous group, 50% had recurrent disease following surgical resection or unresectable lesions surgical resection was successfully attempted in seven of the eight (87.5%) women in the iatrogenic group, with no residual/recurrent disease. None of the patients died of her disease.

Conclusion: Spontaneous and iatrogenic BML can probably be regarded as two separate etiologies of the same pathologic phenomenon, usually with favorable prognosis. However, spontaneous BML may have a less favorable course.

Keywords: benign metastasizing leiomyoma; endoscopic surgery; laparoscopy; morbidity; surgical technique.

PubMed Disclaimer

References

REFERENCES

    1. Awonuga AO, Shavell VI, Imudia AN, Rotas M, Diamond MP, Puscheck EE. Pathogenesis of benign metastasizing leiomyoma: a review. Obstet Gynecol Surv. 2010;65:189-195.
    1. Chen S, Liu RM, Li T. Pulmonary benign metastasizing leiomyoma: a case report and literature review. J Thorac Dis. 2014;6(6):E92-E98.
    1. Chen S, Zhang Y, Zhang J, et al. Pulmonary benign metastasizing leiomyoma from uterine leiomyoma. World J Surg Oncol. 2013;11:163.
    1. Miller J, Shoni M, Siegert C, Lebenthal A, Godleski J, McNamee C. Benign metastasizing leiomyomas to the lungs: an institutional case series and a review of the recent literature. Ann Thorac Surg. 2016;101:253-258.
    1. Anand N, Handler M, Khan A, Wagreich A, Calhoun S. Disseminated peritoneal leiomyomatosis status post laparoscopic hysterectomy with morcellation. J Radiol Case Rep. 2016;10(12):12-18.

LinkOut - more resources