Randomized Controlled Trial

. 2021 Aug;14(8):e009591.

doi: 10.1161/CIRCEP.120.009591. Epub 2021 Jul 16.

Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Jonathan P Piccini¹, Christopher Dufton², Ian A Carroll², Jeff S Healey³, William T Abraham⁴, Yaariv Khaykin⁵, Ryan Aleong⁶, Steven K Krueger⁷, William H Sauer⁸, Stephen B Wilton⁹, Michiel Rienstra¹⁰, Dirk J van Veldhuisen¹⁰, Inder S Anand¹¹, Michel White¹², A John Camm¹³, Paul D Ziegler¹⁴, Debra Marshall², Michael R Bristow^{2

6}, Stuart J Connolly³; Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Atrial Fibrillation/Atrial Flutter in Patients with Heart Failure Trial Investigators*

Collaborators, Affiliations

Collaborators

Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Atrial Fibrillation/Atrial Flutter in Patients with Heart Failure Trial Investigators*:
F Ayala-Paredes, A Bakbak, M L Bernier, D H Birnie, B Coutu, E Crystal, M W Deyell, K M Dyrda, M C Hartleib, Z W Laksman, P Leong-Sit, C A Morillo, A S Pandey, F Philippon, S Vizel, P Andréka, Z Csanadi, G Z Duray, T Forster, G Kerkovits, B Merkely, A C Nagy, T Simor, D Czarnecka, J D Kasprzak, W J Musial, G Raczak, J Szachniewicz, J K Wranicz, S Apostolović, S Hinić, V Miloradović, D Simić, G J Milhous, A Oomen, T J Romer, L M van Vijk, P B Adamson, J D Allred, N Amjadi, M M Bahu, A J Bank, A E Berman, M A Bernabei, R S Bhagwat, L Borgatta, A J Buda, R T Cole, J L Collier, S J Compton, O Costantini, M R Costanzo, I M Dauber, M P Donahue, I Dor, G F Egnacyzk, E J Eichhorn, C C Eiswirth, S Emani, G A Ewald, R C Forde-McLean, M D Gelernt, D E Haines, C A Henrikson, J M Herre, B Herweg, L Ilkhanoff, L R Jackson 2nd, A Lala, R Lo, B London, B D Lowes, J A Mackall, V Malhotra, F A McGrew, S Murali, A Natale, K R Nilsson, J Okolo, M V Perez, R S Phang, R Ranjan, M Y Rashtian, M J Ross, S M Samii, T Shinn, M B Shoemaker, S A Strickberger, V N Tholakanahalli, A Tzur, P J Wang, L T Younis

Affiliations

¹ Duke Clinical Research Institute & Duke University Medical Center, Durham, NC (J.P.P.).
² ARCA biopharma, Inc, Westminster, CO (C.D., I.A.C., D.M., M.R.B.).
³ Population Health Research Institute, McMaster University, Hamilton, ON (J.S.H., S.J.C.).
⁴ Ohio State University Medical Center, Columbus (W.T.A.).
⁵ Southlake Regional Health Center, Newmarket, ON (Y.K.).
⁶ University of Colorado, Aurora (R.A., M.R.B.).
⁷ Nebraska Heart Institute, Lincoln (S.K.K.).
⁸ Brigham and Women's Hospital & Harvard Medical School, Boston, MA (W.H.S.).
⁹ Libin Cardiovascular Institute of Alberta, University of Calgary (S.B.W.).
¹⁰ University of Groningen & University Medical Center Groningen, the Netherlands (M.R., D.J.v.V.).
¹¹ University of Minnesota, Minneapolis (I.S.A.).
¹² Montreal Heart Institute, QC (M.W.).
¹³ St. George's University of London, United Kingdom (A.J.C.).
¹⁴ Medtronic, PLC, Minneapolis, MN (P.D.Z.).

PMID: 34270905
DOI: 10.1161/CIRCEP.120.009591

Free article

Randomized Controlled Trial

Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Jonathan P Piccini et al. Circ Arrhythm Electrophysiol. 2021 Aug.

Free article

. 2021 Aug;14(8):e009591.

doi: 10.1161/CIRCEP.120.009591. Epub 2021 Jul 16.

Authors

Collaborators

Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Atrial Fibrillation/Atrial Flutter in Patients with Heart Failure Trial Investigators*:
F Ayala-Paredes, A Bakbak, M L Bernier, D H Birnie, B Coutu, E Crystal, M W Deyell, K M Dyrda, M C Hartleib, Z W Laksman, P Leong-Sit, C A Morillo, A S Pandey, F Philippon, S Vizel, P Andréka, Z Csanadi, G Z Duray, T Forster, G Kerkovits, B Merkely, A C Nagy, T Simor, D Czarnecka, J D Kasprzak, W J Musial, G Raczak, J Szachniewicz, J K Wranicz, S Apostolović, S Hinić, V Miloradović, D Simić, G J Milhous, A Oomen, T J Romer, L M van Vijk, P B Adamson, J D Allred, N Amjadi, M M Bahu, A J Bank, A E Berman, M A Bernabei, R S Bhagwat, L Borgatta, A J Buda, R T Cole, J L Collier, S J Compton, O Costantini, M R Costanzo, I M Dauber, M P Donahue, I Dor, G F Egnacyzk, E J Eichhorn, C C Eiswirth, S Emani, G A Ewald, R C Forde-McLean, M D Gelernt, D E Haines, C A Henrikson, J M Herre, B Herweg, L Ilkhanoff, L R Jackson 2nd, A Lala, R Lo, B London, B D Lowes, J A Mackall, V Malhotra, F A McGrew, S Murali, A Natale, K R Nilsson, J Okolo, M V Perez, R S Phang, R Ranjan, M Y Rashtian, M J Ross, S M Samii, T Shinn, M B Shoemaker, S A Strickberger, V N Tholakanahalli, A Tzur, P J Wang, L T Younis

Affiliations

¹ Duke Clinical Research Institute & Duke University Medical Center, Durham, NC (J.P.P.).
² ARCA biopharma, Inc, Westminster, CO (C.D., I.A.C., D.M., M.R.B.).
³ Population Health Research Institute, McMaster University, Hamilton, ON (J.S.H., S.J.C.).
⁴ Ohio State University Medical Center, Columbus (W.T.A.).
⁵ Southlake Regional Health Center, Newmarket, ON (Y.K.).
⁶ University of Colorado, Aurora (R.A., M.R.B.).
⁷ Nebraska Heart Institute, Lincoln (S.K.K.).
⁸ Brigham and Women's Hospital & Harvard Medical School, Boston, MA (W.H.S.).
⁹ Libin Cardiovascular Institute of Alberta, University of Calgary (S.B.W.).
¹⁰ University of Groningen & University Medical Center Groningen, the Netherlands (M.R., D.J.v.V.).
¹¹ University of Minnesota, Minneapolis (I.S.A.).
¹² Montreal Heart Institute, QC (M.W.).
¹³ St. George's University of London, United Kingdom (A.J.C.).
¹⁴ Medtronic, PLC, Minneapolis, MN (P.D.Z.).

PMID: 34270905
DOI: 10.1161/CIRCEP.120.009591

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT01970501.

Keywords: atrial fibrillation; atrial flutter; bucindolol; heart failure; metoprolol.

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Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Collaborators

Affiliations

Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Authors

Collaborators

Affiliations

Abstract

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Medical