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Review
. 2021 Sep;6(9):754-769.
doi: 10.1016/S2468-1253(21)00097-2. Epub 2021 Jul 14.

The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease

Alexa N Sasson  1 , Richard J M Ingram  2 , Zhengxiao Zhang  3 , Lorian M Taylor  2 , Ashwin N Ananthakrishnan  1 , Gilaad G Kaplan  4 , Siew C Ng  5 , Subrata Ghosh  6 , Maitreyi Raman  7
Affiliations
Review

The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease

Alexa N Sasson et al. Lancet Gastroenterol Hepatol. 2021 Sep.

Abstract

Inflammatory bowel diseases, principally Crohn's disease and ulcerative colitis, are multifactorial chronic conditions. Alterations in gut microbial patterns partly affect disease onset and severity. Moreover, the evolution of dietary patterns, and their effect on gut microbial behaviour, have been shown to play a crucial role in disease processes. This Viewpoint reviews the role of dietary patterns, their influence on the structure and function of the gut microbiome, and their effects on inflammation and immunity in individuals with inflammatory bowel disease. We also discuss innovative dietary intervention strategies, summarise findings that have been used to develop recommendations for clinical practice, and provide suggestions for the design of future studies for development of precision nutrition in patients with inflammatory bowel disease.

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Conflict of interest statement

Conflict of interests SCN declares being a board member and speaker for Pfizer, Ferring, Janssen, and AbbVie; and speaker at Tillotts, Menarini, and Takeda. GGK has received honoraria for speaking or consultancy from AbbVie, Janssen, Pfizer, and Takeda; he has received research support from Ferring, Janssen, AbbVie, GlaxoSmith Kline, Merck, and Shire; he has been a consultant for Gilead; he shares ownership of a patent (WO2019046959A1. PCT/CA2018/051098). SG reports grants and personal fees from AbbVie; personal fees from Janssen, Takeda, Pfizer, Gilead, Galapagos, Boehringer Ingelheim, BMS, and Celltrion; and grants from GSK, outside the submitted work. All other authors declare no competing interests.

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