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Comment
. 2021 Jul 15;81(14):2871-2872.
doi: 10.1016/j.molcel.2021.06.018.

Nascent RNA: Friend or foe of the chromatin bound?

Usman Hyder  1 , Iván D'Orso  2
Affiliations
Comment

Nascent RNA: Friend or foe of the chromatin bound?

Usman Hyder et al. Mol Cell. .
No abstract available

Plain language summary

In a tour de force, Skalska et al. (2021) discover transcription inhibition and RNA degradation elicit recruitment of chromatin modifiers and transcriptional regulators to chromatin, suggesting a broad role for nascent RNA as factor-chromatin antagonizer.

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Figures

Figure 1.
Figure 1.. Nascent RNA tethers RNA processing factors to chromatin and antagonizes the recruitment of most chromatin regulators to chromatin.
(A) The studies by Skalska et al. suggest: (1) chromatin regulators are relocated from chromatin to nascent RNA during transcription, (2) P-TEFb is transferred from 7SK to 5’SS, and (3) RNA processing factors are tethered to Pol II through interactions with pre-mRNA. (B) Upon in-cell RNAse treatment or transcription inhibition: (1) chromatin regulators gain interactions with chromatin, (2) P-TEFb is released from nascent RNA and associates with chromatin in a 7SK-dependent manner, and (3) RNA processing factors are evicted from chromatin.
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