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. 1987 Dec;43(4):805-11.

An exact test for Hardy-Weinberg and multiple alleles

E J Louis  1 , E R Dempster
Affiliations
  • PMID: 3427165

An exact test for Hardy-Weinberg and multiple alleles

E J Louis et al. Biometrics. 1987 Dec.

Abstract

Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution and is equivalent to Levene's conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.

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