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. 1987 Nov;10(2):197-200.
doi: 10.1007/BF01810583.

Variations in lipoproteins during aminoglutethimide therapy

J Bonneterre  1 , N Ghalim, M Nguyen, P Puchois, A Demaille, C Demarquilly, J C Fruchart
Affiliations

Variations in lipoproteins during aminoglutethimide therapy

J Bonneterre et al. Breast Cancer Res Treat. 1987 Nov.

Abstract

Plasma lipids, apolipoproteins, and gamma-glutamyl-transpeptidase (GGT) were measured in 28 patients receiving aminoglutethimide (500 mg) and hydrocortisone (30 or 40 mg) for advanced breast cancer. A rise in cholesterol (CHOL), LDL-CHOL, apoprotein B, apoprotein CIII, and GGT was observed after 45 days. When the patients were divided in two groups according to lipid basal plasma levels, those with high CHOL and triglyceride did not experience any modification of lipid parameters (only GGT were elevated). Conversely normolipidaemic patients experienced an increase in CHOL, triglycerides, LDL-CHOL, apoproteins B and CIII, and GGT.

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