Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić^#^{1

2

3}, Pollyanna A Goh^#^{2

4}, Aoife Murray^#¹, Erik Portelius^#⁵, Eleni Gkanatsiou⁵, Gillian Gough¹, Kin Y Mok^{4

6}, David Koschut¹, Reinhard Brunmeir¹, Yee Jie Yeap¹, Niamh L O'Brien^{2

4}, Jürgen Groet^{2

4}, Xiaowei Shao¹, Steven Havlicek⁷, N Ray Dunn^{1

8}, Hlin Kvartsberg⁵, Gunnar Brinkmalm⁵, Rosalyn Hithersay^{4

9

10}, Carla Startin^{4

9}, Sarah Hamburg^{4

9}, Margaret Phillips¹¹, Konstantin Pervushin¹¹, Mark Turmaine¹², David Wallon¹³, Anne Rovelet-Lecrux¹³, Hilkka Soininen¹⁴, Emanuela Volpi¹⁵, Joanne E Martin², Jia Nee Foo^{1

7}, David L Becker¹, Agueda Rostagno¹⁶, Jorge Ghiso¹⁶, Željka Krsnik¹⁷, Goran Šimić¹⁷, Ivica Kostović¹⁷, Dinko Mitrečić¹⁷; LonDownS Consortium; Paul T Francis¹⁸, Kaj Blennow⁵, Andre Strydom^{4

9

10}, John Hardy^{4

6}, Henrik Zetterberg^{5

6}, Dean Nižetić^{19

20

21}

Collaborators, Affiliations

Collaborators

LonDownS Consortium:
Andre Strydom, Elizabeth Fisher, Frances Wiseman, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.
² The Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, E1 2AT, UK.
³ Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, 10000, Zagreb, Croatia.
⁴ LonDownS Consortium, London, UK.
⁵ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, S-405 30, Sweden.
⁶ Dementia Research Institute & Reta Lila Weston Institute, Institute of Neurology, University College London, London, WC1N 3BG, UK.
⁷ Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
⁸ Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.
⁹ Division of Psychiatry, University College London, London, WC1E 6BT, UK.
¹⁰ Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
¹¹ School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore.
¹² Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, UK.
¹³ Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
¹⁴ University of Eastern Finland, Institute of Clinical Medicine/Neurology, Kuopio, FI-70211, Finland.
¹⁵ School of Life Sciences, University of Westminster, London, W1W 6UW, UK.
¹⁶ Department of Pathology & Department of Psychiatry, New York University School of Medicine, New York, NY, 10016, USA.
¹⁷ Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia.
¹⁸ Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, UK.
¹⁹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. d.nizetic@qmul.ac.uk.
²⁰ The Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, E1 2AT, UK. d.nizetic@qmul.ac.uk.
²¹ LonDownS Consortium, London, UK. d.nizetic@qmul.ac.uk.

^# Contributed equally.

PMID: 34272490
PMCID: PMC9119252
DOI: 10.1038/s41380-021-01206-x

Published Erratum

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić et al. Mol Psychiatry. 2021 Oct.

. 2021 Oct;26(10):5789.

doi: 10.1038/s41380-021-01206-x.

Authors

Collaborators

LonDownS Consortium:
Andre Strydom, Elizabeth Fisher, Frances Wiseman, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.
² The Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, E1 2AT, UK.
³ Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, 10000, Zagreb, Croatia.
⁴ LonDownS Consortium, London, UK.
⁵ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, S-405 30, Sweden.
⁶ Dementia Research Institute & Reta Lila Weston Institute, Institute of Neurology, University College London, London, WC1N 3BG, UK.
⁷ Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
⁸ Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.
⁹ Division of Psychiatry, University College London, London, WC1E 6BT, UK.
¹⁰ Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
¹¹ School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore.
¹² Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, UK.
¹³ Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
¹⁴ University of Eastern Finland, Institute of Clinical Medicine/Neurology, Kuopio, FI-70211, Finland.
¹⁵ School of Life Sciences, University of Westminster, London, W1W 6UW, UK.
¹⁶ Department of Pathology & Department of Psychiatry, New York University School of Medicine, New York, NY, 10016, USA.
¹⁷ Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia.
¹⁸ Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, UK.
¹⁹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. d.nizetic@qmul.ac.uk.
²⁰ The Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, E1 2AT, UK. d.nizetic@qmul.ac.uk.
²¹ LonDownS Consortium, London, UK. d.nizetic@qmul.ac.uk.

^# Contributed equally.

PMID: 34272490
PMCID: PMC9119252
DOI: 10.1038/s41380-021-01206-x

No abstract available

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Erratum for

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium; Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D. Alić I, et al. Mol Psychiatry. 2021 Oct;26(10):5766-5788. doi: 10.1038/s41380-020-0806-5. Epub 2020 Jul 10. Mol Psychiatry. 2021. PMID: 32647257 Free PMC article.

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Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

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Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

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