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Comment
. 2021 Oct 22;144(9):e76.
doi: 10.1093/brain/awab277.

Reply: Looking beyond indirect lesion network mapping of prosopagnosia: direct measures required

Alexander L Cohen  1   2   3 , Michael D Fox  3   4   5
Affiliations
Comment

Reply: Looking beyond indirect lesion network mapping of prosopagnosia: direct measures required

Alexander L Cohen et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
A consistent relationship is seen between lesion locations and an identified ‘prosopagnosia network’ with alternative functional connectivity preprocessing algorithms. The traced/segmented bilateral lesion from Subject EP (A, hot colours) as well as the VBM-derived right-sided lesion (A, green) both fall squarely within the proposed ‘prosopagnosia network’ from Cohen et al. (A, purple), and avoid the right FFA (A, red). Brain regions functionally connected to the VBM-derived right hemisphere lesion were then obtained using the ‘GSP1000’ large resting state functional connectivity database (B), demonstrating strong positive connectivity with the right FFA (B, now shown in blue) as well as negative connectivity with the left anterior prefrontal cortex (APFC), the left middle frontal gyrus (MFG), the dorsal anterior cingulate cortex (ACC), and the left superior frontal gyrus (SFG) (B, red regions). Region–region connectivity between Subject EP’s lesion and the identified critical regions from Cohen et al. (C, green circles) was also consistent with the original findings from Cohen et al. when using Global Signal Regression (GSR) (C, left) or when an alternative artefact regression method, such as aCompCor, is used for preprocessing (C, right). Note that in GSR processed data, uninformative connections are distributed around zero, allowing for symmetric thresholds to be used, while in aCompCor processed data, uninformative connections are distributed in the positive range (∼0–0.2), requiring asymmetric thresholds for functional connectivity analyses. (All correlation distributions are significantly different from zero, P < 0.001.) Red lines in box plots indicate medians while stars indicate means.
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References

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