Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct;65(9):1351-1354.
doi: 10.1111/aas.13953. Epub 2021 Aug 12.

Patient and public involvement in contemporary large intensive care trials: Protocol for a meta-epidemiological study

Emily Barot  1 , Maj-Brit Nørregaard Kjaer  1 , Marie Collet  1 , Elena Crescioli  2 , Bodil Steen Rasmussen  2 , Stine Estrup  3 , Camilla Bekker Mortensen  3 , Gitte Kingo Vesterlund  1 , Praleene Sivapalan  1 , Carl Thomas Anthon  1 , Camilla Rahbek Lysholm Bruun  1 , Lone Musaeus Poulsen  3 , Morten Hylander Møller  1 , Anders Perner  1 , Anders Granholm  1
Affiliations
Review

Patient and public involvement in contemporary large intensive care trials: Protocol for a meta-epidemiological study

Emily Barot et al. Acta Anaesthesiol Scand. 2021 Oct.

Abstract

Background: Patient and public involvement (PPI) in randomized clinical trials (RCTs) has increased in recent years but remains the exception rather than the rule. We aim to assess the frequency and extent of PPI in large, contemporary RCTs conducted in an intensive care setting.

Methods and design: We will conduct a meta-epidemiological study of RCTs conducted in intensive care settings published since 2019 and assess their use of PPI. We will extract trial characteristics and verify the use of PPI with trial authors unless specifically stated in the published paper. The primary outcome will be the proportion of trials that use PPI. Secondary outcomes will explore which groups are consulted, at which stage of the trial process this occurs, and by what means these opinions are collected and implemented.

Discussion: This meta-epidemiological study will provide an important insight into the use of PPI in large, contemporary intensive care trials. We wish to reveal ways in which patient involvement could be incorporated more broadly and purposefully here and help to empower clinicians, researchers and patients to collaborate further on future research processes and goals.

PubMed Disclaimer

References

REFERENCES

    1. Boote J, Wong R, Booth A. “Talking the talk or walking the walk?” A bibliometric review of the literature on public involvement in health research published between 1995 and 2009. Health Expect. 2015;18(1):44-57.
    1. Sacristán JA, Aguarón A, Avendaño-Solá C, et al. Patient involvement in clinical research: Why, when, and how. Patient Preference and Adherence. 2016;10:631-640.
    1. Lloyd K, White J. Lloyd-2012-474277a. Nature. 2011;474:277-278.
    1. Pii KH, Schou LH, Piil K, Jarden M. Current trends in patient and public involvement in cancer research: A systematic review. Health Expect. 2019;22(1):3-20.
    1. Cowan K. The James Lind Alliance. Journal of Ambulatory Care Management. 2010;33(3):241-248.

LinkOut - more resources