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Review
. 2021 Aug 7;398(10299):535-554.
doi: 10.1016/S0140-6736(21)00312-3. Epub 2021 Jul 21.

Lung cancer

Alesha A Thai  1 , Benjamin J Solomon  1 , Lecia V Sequist  2 , Justin F Gainor  2 , Rebecca S Heist  3
Affiliations
Review

Lung cancer

Alesha A Thai et al. Lancet. .

Abstract

Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and refinements in treatment have led to remarkable progress in the past two decades and transformed outcomes for many patients. This seminar provides an overview of advances in the screening, diagnosis, and treatment of non-small-cell lung cancer and small-cell lung cancer, with a particular focus on targeted therapies and immune checkpoint inhibitors.

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Conflict of interest statement

Declaration of interests BJS reports personal fees from Pfizer, Novartis, Roche/Genentech, AstraZeneca, Merck, Bristol Myers Squibb, Amgen, and Loxo Oncology outside the submitted work. JFG has served as a consultant or received honoraria from Bristol-Myers Squibb, Genentech, Ariad/Takeda, Loxo/Lilly, Blueprint, Oncorus, Regeneron, Gilead, Helsinn, EMD Serono, AstraZeneca, Pfizer, Incyte, Novartis, Merck, Agios, Amgen, and Array; has had research support from Novartis, Genentech/Roche, Ariad/Takeda, Bristol-Myers Squibb, Tesaro, Moderna, Blueprint, Jounce, Array Biopharma, Merck, Adaptimmune, and Alexo; and has an immediate family member who is an employee of Ironwood Pharmaceuticals. LVS reports grants and personal fees from AstraZeneca; grants from Novartis and Boehringer Ingelheim; grants and consulting fees from Genentech Blueprint and Merrimack Pharmaceuticals; and consulting fees from Janssen and grants from LOXO, all outside the submitted work. LVS has a patent about treatment of EGFR-mutant cancer pending. RSH reports honoraria from Novartis, Merck KGaA, Daichii Sankyo, Pfizer, Roche, Apollomics, Tarveda, and Boehringer Ingelheim; and grants from Novartis, Genentech Roche, Corvus, Incyte, Exelixis, Abbvie, Daichii Sankyo, Agios, Mirati, Turning Point, and Lilly when writing this Seminar. AAT declares no competing interests.

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