Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct;35(5):895-911.
doi: 10.1016/j.hoc.2021.05.003. Epub 2021 Jul 14.

Lip and Oral Cavity Squamous Cell Carcinoma

Adam Howard  1 , Nishant Agrawal  1 , Zhen Gooi  2
Affiliations
Review

Lip and Oral Cavity Squamous Cell Carcinoma

Adam Howard et al. Hematol Oncol Clin North Am. 2021 Oct.

Abstract

Lip and oral cavity squamous cell carcinoma (SCC) develop from progressive dysplasia of these mucosal structures. The cancers are often preceded by premalignant lesions, and any nonhealing ulcers of the lip or oral cavity should be biopsied. Some risk factors for these 2 subsites overlap and include tobacco use, alcohol use, and an immunocompromised state. Lip and oral cavity SCC are clinically staged based on physical examination and imaging. The 5-year overall survival for early-stage lip and oral cavity SCC is around 70% to 90% but decreases to about 50% for late-stage disease.

Keywords: Head and neck cancer; Lip cancer; Oral cavity cancer; Squamous cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

Disclosure Nothing to disclose.