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Review
. 2021 Sep:138:106041.
doi: 10.1016/j.biocel.2021.106041. Epub 2021 Jul 15.

Why is PAK4 overexpressed in cancer?

Tânia D F Costa  1 , Staffan Strömblad  2
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Free article
Review

Why is PAK4 overexpressed in cancer?

Tânia D F Costa et al. Int J Biochem Cell Biol. 2021 Sep.
Free article

Abstract

Understanding why proteins are overexpressed in cancer is of great interest, as it holds the potential for improved cancer diagnosis and treatment. A noteworthy candidate, p21-activated kinase 4 (PAK4), is frequently overexpressed in cancer and a key player in multiple hallmarks of cancer. Here we review findings backing PAK4 overexpression in cancer and motivate PAK4 as a suitable target for the development of cancer therapy.

Keywords: Cancer; Cellular senescence; Protein overexpression; p21-activated kinase.

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