Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations

Ola Undrum Bergland^{1

2}, Lene V Halvorsen^{1

3

2}, Camilla L Søraas^{1

4}, Ulla Hjørnholm¹, Vibeke N Kjær¹, Stine Rognstad^{1

5

2}, Karl Marius Brobak^{6

7}, Arleen Aune^{8

9}, Eirik Olsen¹⁰, Ylva M Fauchald¹, Sondre Heimark^{1

3

2}, Christian W Thorstensen⁵, Knut Liestøl¹¹, Marit D Solbu^{6

7}, Eva Gerdts^{8

9}, Rune Mo¹⁰, Morten Rostrup^{1

12

13}, Sverre E Kjeldsen^{1

14

2}, Aud Høieggen^{1

3

2}, Mimi S Opdal⁵, Anne Cecilie K Larstorp^{1

15

2}, Fadl Elmula M Fadl Elmula^{1

12}

Affiliations

¹ From the Section for Cardiovascular and Renal Research (O.U.B., L.V.H., C.L.S., U.H., V.N.K., S.R., Y.M.F., S.H., M.R., S.E.K., A.H., A.C.K.L., F.E.M.F.E.).
² Oslo University Hospital Ullevål; Institute of Clinical Medicine (O.U.B., L.V.H., S.R., S.H., S.E.K., A.H., A.C.K.L.), University of Oslo.
³ Department of Nephrology (L.V.H., S.H., A.H.).
⁴ Section for Environmental and Occupational Medicine (C.L.S.).
⁵ Department of Pharmacology (S.R., C.W.T., M.S.O.).
⁶ Metabolic and Renal Research Group (K.M.B., M.D.S.), University Hospital of North Norway, Tromsø.
⁷ UiT The Arctic University of Norway, and Section of Nephrology (K.M.B., M.D.S.), University Hospital of North Norway, Tromsø.
⁸ Department of Clinical Science, University of Bergen (A.A., E.G.).
⁹ Department of Heart Disease, Haukeland University Hospital, Bergen (A.A., E.G.).
¹⁰ Department of Cardiology, Trondheim University Hospital, University of Trondheim (E.O., R.M.).
¹¹ Department of Informatics (K.L.), University of Oslo.
¹² Department of Acute Medicine (M.R., F.E.M.F.E.).
¹³ Department of Behavioral Sciences, Institute of Basic Medical Sciences (M.R.), University of Oslo.
¹⁴ Department of Cardiology (S.E.K.).
¹⁵ Department of Medical Biochemistry (A.C.K.L.).

Ola Undrum Bergland et al. Hypertension. 2021 Sep.

. 2021 Sep;78(3):617-628.

doi: 10.1161/HYPERTENSIONAHA.121.17514. Epub 2021 Jul 19.

¹ From the Section for Cardiovascular and Renal Research (O.U.B., L.V.H., C.L.S., U.H., V.N.K., S.R., Y.M.F., S.H., M.R., S.E.K., A.H., A.C.K.L., F.E.M.F.E.).
² Oslo University Hospital Ullevål; Institute of Clinical Medicine (O.U.B., L.V.H., S.R., S.H., S.E.K., A.H., A.C.K.L.), University of Oslo.
³ Department of Nephrology (L.V.H., S.H., A.H.).
⁴ Section for Environmental and Occupational Medicine (C.L.S.).
⁵ Department of Pharmacology (S.R., C.W.T., M.S.O.).
⁶ Metabolic and Renal Research Group (K.M.B., M.D.S.), University Hospital of North Norway, Tromsø.
⁷ UiT The Arctic University of Norway, and Section of Nephrology (K.M.B., M.D.S.), University Hospital of North Norway, Tromsø.
⁸ Department of Clinical Science, University of Bergen (A.A., E.G.).
⁹ Department of Heart Disease, Haukeland University Hospital, Bergen (A.A., E.G.).
¹⁰ Department of Cardiology, Trondheim University Hospital, University of Trondheim (E.O., R.M.).
¹¹ Department of Informatics (K.L.), University of Oslo.
¹² Department of Acute Medicine (M.R., F.E.M.F.E.).
¹³ Department of Behavioral Sciences, Institute of Basic Medical Sciences (M.R.), University of Oslo.
¹⁴ Department of Cardiology (S.E.K.).
¹⁵ Department of Medical Biochemistry (A.C.K.L.).

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT03209154.

Keywords: blood pressure; body fluids; hypertension; prevalence; tandem mass-spectrometry.