Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis

Abolfazl Avan¹, Amin Amiri², Naghmeh Mokhber³, Mahdiyeh Erfanian⁴, Lauren E Cipriano⁵, Saverio Stranges⁶, Golnaz Shojaeianbabaei¹, Shahram Abootalebi⁷, M Reza Azarpazhooh⁸

Affiliations

¹ Department of Public Health, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Psychiatry, St Joseph's Health Care London, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Psychiatry and Behavioral Neurosciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁴ Department of Statistics, Ferdowsi University of Mashhad, Mashhad, Iran.
⁵ Ivey Business School, University of Western Ontario, London, ON, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁶ Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Family Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.
⁷ Dr. Everett Chalmers Regional Hospital, Dalhousie University, New Brunswick, Canada.
⁸ Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. Electronic address: reza.azarpazhooh@lhsc.on.ca.

PMID: 34275535
DOI: 10.1016/j.jocn.2021.05.044

Meta-Analysis

Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis

Abolfazl Avan et al. J Clin Neurosci. 2021 Aug.

. 2021 Aug:90:124-131.

doi: 10.1016/j.jocn.2021.05.044. Epub 2021 Jun 7.

Authors

Abolfazl Avan¹, Amin Amiri², Naghmeh Mokhber³, Mahdiyeh Erfanian⁴, Lauren E Cipriano⁵, Saverio Stranges⁶, Golnaz Shojaeianbabaei¹, Shahram Abootalebi⁷, M Reza Azarpazhooh⁸

Affiliations

¹ Department of Public Health, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Psychiatry, St Joseph's Health Care London, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Psychiatry and Behavioral Neurosciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁴ Department of Statistics, Ferdowsi University of Mashhad, Mashhad, Iran.
⁵ Ivey Business School, University of Western Ontario, London, ON, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁶ Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Family Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.
⁷ Dr. Everett Chalmers Regional Hospital, Dalhousie University, New Brunswick, Canada.
⁸ Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. Electronic address: reza.azarpazhooh@lhsc.on.ca.

PMID: 34275535
DOI: 10.1016/j.jocn.2021.05.044

Abstract

Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia.

Methods: We searched for community-based cohorts with postmortem brain autopsy until 1 January 2020. We calculated the summary risk difference and 95% confidence interval (95% CI) using a random-effects model in R.

Results: We found 12 articles, comprising 2197 demented and 2104 non-demented participants. LB, HS, CAA were prevalent lesions among community-dwelling elderly (15%, 10%, and 24%, respectively). These significantly increased the risk of dementia (LB: risk difference 38%, 95% CI 20-56%, HS: 34%, 24-44%, CAA: 19%, 3-34%). 20% of cases with neocortical LB, 17% with bilateral HS, and 42% with moderate/severe CAA pathology remained non-demented by death.

Discussion: LB or HS or CAA are common neuropathologies among community-dwelling elderly. Although these lesions independently are associated with dementia, many remain non-demented, by death.

Keywords: Cerebral amyloid angiopathy; Community-dwelling elderly; Dementia; Hippocampal sclerosis; Lewy body; Prevalence.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis

Affiliations

Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

LinkOut - more resources

Full Text Sources

Medical