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Review
. 2021 Jun 30:12:664577.
doi: 10.3389/fimmu.2021.664577. eCollection 2021.

Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

Abraham J Matar  1 , Rebecca L Crepeau  1 , Gerhard S Mundinger  2 , Curtis L Cetrulo Jr  3   4   5 , Radbeh Torabi  2
Affiliations
Review

Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

Abraham J Matar et al. Front Immunol. .

Abstract

Over the past twenty years, significant technical strides have been made in the area of vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation, the allogeneic immune response remains a significant barrier to long-term VCA survival and function. Strategies to overcome acute and chronic rejection, minimize immunosuppression and prolong VCA survival have important clinical implications. Historically, large animals have provided a valuable model for testing the clinical translatability of immune modulating approaches in transplantation, including tolerance induction, co-stimulation blockade, cellular therapies, and ex vivo perfusion. Recently, significant advancements have been made in these arenas utilizing large animal VCA models. In this comprehensive review, we highlight recent immune strategies undertaken to improve VCA outcomes with a focus on relevant preclinical large animal models.

Keywords: cellular therapies; ex vivo perfusion; large animal model; transplantation tolerance induction; vascularized composite allograft.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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