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Meta-Analysis
. 2021 May 14;4(3):e00260.
doi: 10.1002/edm2.260. eCollection 2021 Jul.

Anaemia and its associated factors among diabetes mellitus patients in Ethiopia: A systematic review and meta-analysis

Tiruneh Adane  1 , Solomon Getawa  1
Affiliations
Meta-Analysis

Anaemia and its associated factors among diabetes mellitus patients in Ethiopia: A systematic review and meta-analysis

Tiruneh Adane et al. Endocrinol Diabetes Metab. .

Abstract

Introduction: Anaemia is common but often overlooked in diabetes mellitus (DM) patients. There is also no official nationwide survey registry that estimated the prevalence of anaemia in DM patients in Ethiopia. Therefore, the main aim of this study is to determine the countrywide pooled prevalence and associated factors of anaemia in DM patients.

Methods: This systematic review and meta-analysis were conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. STATA 11 software was used for all statistical analysis. Random effects model was used to estimate the pooled prevalence of anaemia and associated factors at a 95% confidence interval (CI) with its respective odds ratio (OR). Subgroup analysis and egger test were used to determine heterogeneity and publication bias, respectively.

Results: Nine articles were included in this systematic review and meta-analysis with a total of 2889 DM patients. The pooled prevalence of anaemia among DM patients in Ethiopia was 22.11% (95% CI: 15.83-28.39) I 2 = 94.8%. The prevalence of anaemia in type I and type II DM patients was (16.78% [95% CI: 11.53-22.04]) and (31.12% [95% CI; 9.66-52.58]), respectively. The prevalence of anaemia was higher among male (36.72% [95% CI: 22.58-50.87] I 2 = 97.6%) than female (27.51% [95% CI: 16.12-38.90] I 2 = 96.3%). Moreover, the odds of anaemia were higher among patients with age ˃ 60 (OR = 2.98; 95% CI: 1.83, 4.87), low estimated glomerular filtration rate (eGFR) (OR = 8.59; 95% CI: 4.76, 15.57), and duration of illness ≥5 years (OR = 2.66; 95%: 1.38, 5.13).

Conclusions: The result of this review implies that anaemia is a moderate public health problem among DM patients in Ethiopia. Older age, poor glycemic control, low eGFR and longer duration of illness were found to be the contributing factors for the development of anaemia in DM patients. Therefore, by considering the negative impact of anaemia, it is important to include anaemia screening into routine assessment of DM-related complications targeting patients with older age, poor glycemic control, low eGFR, and longer duration of illness to reduce the magnitude of the problem.

Keywords: Ethiopia; anaemia; diabetes mellitus; meta‐analysis; systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Flow chart to describe the selection of studies for the systematic review and meta‐analysis on the prevalence of anaemia among DM patients in Ethiopia
FIGURE 2
FIGURE 2
Forest plot displaying the pooled prevalence of anaemia among DM patients
FIGURE 3
FIGURE 3
Forest plots which describe associated factors (age and duration of illness) of anaemia among DM patients in Ethiopia
FIGURE 4
FIGURE 4
Forest plots which describe associated factors (low eGFR and poor glycemic control) of anaemia among DM patients in Ethiopia
FIGURE 5
FIGURE 5
Funnel plot of included studies on the prevalence of anaemia among DM patients
See this image and copyright information in PMC

References

    1. Organization WHO . Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation; 2006.
    1. Federation IDF . IDF Diabetes Atlas 9th Edition 2019. Available at https://www.diabetesatlas.org/en/
    1. Nshisso LD, Reese A, Gelaye B, et al. Prevalence of hypertension and diabetes among Ethiopian adults. Diabet Metab Syndr Clin Res Rev. 2012;6:36‐41. - PMC - PubMed
    1. Kasper D, Harrison TR. Harrison's Principles of Internal Medicine, Vol. 1. United States: McGraw‐Hill, Medical Publishing Division; 2005.
    1. Mbata C, Adegoke A, Nwagu C, et al. Some haematological parameters in diabetic patients in Port Harcourt Nigeria. AJMS. 2015;3:2348‐7186.