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. 2021 Oct;47(10):3677-3690.
doi: 10.1111/jog.14937. Epub 2021 Jul 18.

Vasomotor symptoms, sleep problems, and depressive symptoms in community-dwelling Japanese women

Makiko Tomida  1 , Rei Otsuka  1 , Chikako Tange  1 , Yukiko Nishita  1 , Tomomi Kimura  2 , Matthias Stoelzel  3 , Keiko Tanaka-Amino  4 , Hiroshi Shimokata  1   5 , Masakazu Terauchi  6
Affiliations

Vasomotor symptoms, sleep problems, and depressive symptoms in community-dwelling Japanese women

Makiko Tomida et al. J Obstet Gynaecol Res. 2021 Oct.

Abstract

Aim: To assess prevalence and characteristics of vasomotor symptoms in community-dwelling Japanese women.

Methods: These were cross-sectional analyses using data from the National Institute for Longevity Sciences-Longitudinal Study of Aging. The main outcome measures were prevalence and severity of hot flashes and sweating. Associations between hot flashes/sweating (slight, moderate, or severe vs none) and sleep problems were explored using logistic regression, with and without adjustment for age, daily physical activity, and number of urinations/night. Associations between hot flashes/sweating and sleep problems, depressive symptoms, and dietary variables were explored in logistic regression models or general linear models.

Results: A total of 1152 women between 40 and 91 years of age were enrolled. Hot flashes were reported by 24.5% of participants; with prevalence and severity highest in those 50-54 years or 2-5 years postmenopause. Sleep problems were reported 15 percentage points more frequently by women who reported hot flashes than by those without hot flashes. Adjusted odds ratios [95% CI] for difficulty in falling asleep and difficulty in sleeping through were 2.09 [1.565-2.796] and 2.07 [1.549-2.763]), respectively. Also, hot flashes were associated with higher risk of depressive symptoms (adjusted odds ratio [95% CI]: 2.99 [2.07-4.32]) and lower life satisfaction, self-esteem, and self-rated health status. A similar pattern was observed in women with and without sweating. No associations were found between hot flashes and dietary factors.

Conclusions: Clear associations were found between hot flashes and sleeping problems, even after adjusting for potential confounding factors. Women who reported hot flashes also reported worse mental and physical health than those who did not report hot flashes.

Keywords: Japan; depressive symptoms; hot flashes; menopause; sleep.

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Conflict of interest statement

Makiko Tomida, Rei Otsuka, Chikako Tange, Yukiko Nishita, and Hiroshi Shimokata report (F) research funding from Astellas Pharma Inc. Tomomi Kimura, Matthias Stoelzel, and Keiko Tanaka‐Amino are (A) employees of Astellas Pharma. Masakazu Terauchi reports (F) grants from Kikkoman Corporation and Ibaraki Prefecture, and (G) personal fees from Fuji Pharma Co. Ltd., personal fees from Bayer Holding Ltd., and personal fees from Hisamitsu Pharmaceutical Co., Inc.

Figures

Figure 1
Figure 1
Prevalence of hot flashes and sweating by (a) age group and (b) time from menopause
Figure 2
Figure 2
Prevalence of mild, moderate, and severe hot flashes by age group
See this image and copyright information in PMC

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