Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

doi:10.3390/molecules26134036

Review

. 2021 Jul 1;26(13):4036.

doi: 10.3390/molecules26134036.

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Laxman Singh¹, Shikha Sharma², Suowen Xu³, Devesh Tewari², Jian Fang⁴

Affiliations

¹ Centre of Biodiversity Conservation & Management, G.B.Pant National Institute of Himalayan Environment, Almora 263643, Uttarakhand, India.
² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.
³ Department of Endocrinology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230037, China.
⁴ Department of Pharmacy, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.

PMID: 34279384
PMCID: PMC8272048
DOI: 10.3390/molecules26134036

Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Laxman Singh et al. Molecules. 2021.

. 2021 Jul 1;26(13):4036.

doi: 10.3390/molecules26134036.

Authors

Laxman Singh¹, Shikha Sharma², Suowen Xu³, Devesh Tewari², Jian Fang⁴

Affiliations

¹ Centre of Biodiversity Conservation & Management, G.B.Pant National Institute of Himalayan Environment, Almora 263643, Uttarakhand, India.
² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.
³ Department of Endocrinology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230037, China.
⁴ Department of Pharmacy, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.

PMID: 34279384
PMCID: PMC8272048
DOI: 10.3390/molecules26134036

Abstract

Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.

Keywords: atherosclerosis; curcumin; pharmacology; therapeutics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Pharmacological effects and mechanism of action of curcumin in atherosclerosis.

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References

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[1] Hannawi S., Hannawi H., Al Salmi I. Cardiovascular disease and subclinical atherosclerosis in rheumatoid arthritis. Hypertens. Res. 2020;43:982–984. doi: 10.1038/s41440-020-0483-4. - DOI - PubMed

[2] Hannawi S., Hannawi H., Al Salmi I. Cardiovascular disease and subclinical atherosclerosis in rheumatoid arthritis. Hypertens. Res. 2020;43:982–984. doi: 10.1038/s41440-020-0483-4. - DOI - PubMed

[3] Bi C., Fu Y., Li B. Brain-derived neurotrophic factor alleviates diabetes mellitus-accelerated atherosclerosis by promoting M2 polarization of macrophages through repressing the STAT3 pathway. Cell. Signal. 2020;70:109569. doi: 10.1016/j.cellsig.2020.109569. - DOI - PubMed

[4] Bi C., Fu Y., Li B. Brain-derived neurotrophic factor alleviates diabetes mellitus-accelerated atherosclerosis by promoting M2 polarization of macrophages through repressing the STAT3 pathway. Cell. Signal. 2020;70:109569. doi: 10.1016/j.cellsig.2020.109569. - DOI - PubMed

[5] Ito K., Maeda T., Tada K., Takahashi K., Yasuno T., Masutani K., Mukoubara S., Arima H., Nakashima H. The role of cigarette smoking on new-onset of chronic kidney disease in a Japanese population without prior chronic kidney disease: Iki epidemiological study of atherosclerosis and chronic kidney disease (ISSA-CKD) Clin. Exp. Nephrol. 2020;24:919–926. doi: 10.1007/s10157-020-01914-8. - DOI - PubMed

[6] Ito K., Maeda T., Tada K., Takahashi K., Yasuno T., Masutani K., Mukoubara S., Arima H., Nakashima H. The role of cigarette smoking on new-onset of chronic kidney disease in a Japanese population without prior chronic kidney disease: Iki epidemiological study of atherosclerosis and chronic kidney disease (ISSA-CKD) Clin. Exp. Nephrol. 2020;24:919–926. doi: 10.1007/s10157-020-01914-8. - DOI - PubMed

[7] Miao J., Zang X., Cui X., Zhang J. Autophagy, Hyperlipidemia, and Atherosclerosis. Adv. Exp. Med. Biol. 2020;1207:237–264. doi: 10.1007/978-981-15-4272-5_18. - DOI - PubMed

[8] Miao J., Zang X., Cui X., Zhang J. Autophagy, Hyperlipidemia, and Atherosclerosis. Adv. Exp. Med. Biol. 2020;1207:237–264. doi: 10.1007/978-981-15-4272-5_18. - DOI - PubMed

[9] Ye J., Wang Y., Wang Z., Liu L., Yang Z., Wang M., Xu Y., Ye D., Zhang J., Zhou Q., et al. The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis. Mediat. Inflamm. 2020;2020:2369279. doi: 10.1155/2020/2369279. - DOI - PMC - PubMed

[10] Ye J., Wang Y., Wang Z., Liu L., Yang Z., Wang M., Xu Y., Ye D., Zhang J., Zhou Q., et al. The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis. Mediat. Inflamm. 2020;2020:2369279. doi: 10.1155/2020/2369279. - DOI - PMC - PubMed

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Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Affiliations

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

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Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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Medical