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Review
. 2021:1327:169-189.
doi: 10.1007/978-3-030-71697-4_14.

Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19)

Victor B Hsue  1 , Kyohei Itamura  1 , Arthur W Wu  1 , Elisa A Illing  2 , Kevin J Sokoloski  3 , Bree A Weaver  4 , Benjamin P Anthony  2 , Nathan Hughes  5 , Jonathan Y Ting  2 , Thomas S Higgins  6   7
Affiliations
Review

Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19)

Victor B Hsue et al. Adv Exp Med Biol. 2021.

Abstract

With the largest viral loads in both symptomatic and asymptomatic patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) present in the oral and nasal cavities, agents that act on these two areas have the potential for large therapeutic and prophylactic benefit. A literature review was conducted to elucidate the possible agents useful in treatment of SARS-CoV-2. These agents were evaluated for their current applications, adverse reactions, their current state of study, and any future considerations in their management of coronavirus disease 2019 (COVID-2019). Our review has found that, while there are many promising agents with proven efficacy in their in-vitro efficacy against SARS-CoV-2, more clinical trials and in-vivo studies, as well as safety trials, must be conducted before these agents can be effectively implemented.

Keywords: Antiviral agents; COVID-19; Coronavirus; Nasal; Nasopharynx; Oral; Public health; Severe acute respiratory syndrome coronavirus 2; Topical.

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References

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