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. 2021 Jul 19;105(3):596-599.
doi: 10.4269/ajtmh.21-0009.

Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study

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Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study

David Vandroux et al. Am J Trop Med Hyg. .

Abstract

This retrospective and single-center study in Reunion Island (Indian Ocean) assessed frequency, mortality, causative pathogens of severe necrotizing skin, and necrotizing skin and soft tissue infections (NSSTIs) admitted in intensive care unit (ICU). Sixty-seven consecutive patients were included from January 2012 to December 2018. Necrotizing skin and soft tissue infection represented 1.06% of total ICU admissions. We estimate the incidence of NSSTI requiring ICU at 1.21/100,000 person/years in Reunion Island. Twenty (30%) patients were receiving nonsteroidal anti-inflammatory drugs (NSAIDs) prior to admission in ICU and 40 (60%) were diagnosed patients with diabetes. Sites of infection were the lower limb in 52 (78%) patients, upper limb in 4 (6%), and perineum in 10 (15%). The surgical treatment was debridement for 40 patients, whereas 11 patients required an amputation. The most commonly isolated microorganisms were Streptococci (42%) and Gram-negative bacteria (22%).The mortality rate was 25.4%. NSAIDs did not influence mortality when interrupted upon admission to ICU.

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References

    1. George SM, Harrison DA, Welch CA, Nolan KM, Friedmann PS, 2008. Dermatological conditions in intensive care: a secondary analysis of the Intensive Care National Audit and Research Centre (ICNARC) Case Mix Programme database. Crit Care 12 (Suppl 1): S1. - PMC - PubMed
    1. Chosidow O, Saiag P, Pinquier L, Bastuji-Garin S, Revuz J, Roujeau JC, 1991. Nonsteroidal anti-inflammatory drugs in cellulitis: a cautionary note. Arch Dermatol 127: 1845–1846. - PubMed
    1. Rimailho A, Riou B, Richard C, 1987. Auzepy. Fulminant necrotizing fasciitis and nonsteroidal anti-inflammatory drugs. J Infect Dis 155: 143–146. - PMC - PubMed
    1. Bryant AE, Bayer CR, Aldape MJ, Stevens DL, 2015. The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections. Curr Opin Infect Dis 28: 231–239. - PMC - PubMed
    1. Lesko SM, O’Brien KL, Schwartz B, Vezina R, Mitchell AA, 2001. Invasive group A streptococcal infection and nonsteroidal antiinflammatory drug use among children with primary varicella. Pediatrics 107: 1108–1115. - PubMed

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