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Editorial
. 2021 Nov;161(5):1376-1378.
doi: 10.1053/j.gastro.2021.07.020. Epub 2021 Jul 16.

SIRT5's GOT1 up on PDAC

Surinder Kumar  1 , David B Lombard  2
Affiliations
Editorial

SIRT5's GOT1 up on PDAC

Surinder Kumar et al. Gastroenterology. 2021 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures: The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.. Major roles for SIRT5 in cancer cell metabolism.
Via deacylation (blue), SIRT5 regulates the activities of various metabolic enzymes (yellow) and functions as either an oncogene (red) or a tumor suppressor (green), in a context-specific manner. SHMT2, mitochondrial serine hydroxymethyltransferase; PKM2, pyruvate kinase muscle isozyme 2; GLS, glutaminase; GLUD1, glutamate dehydrogenase 1; CS, citrate synthase; SOD1, Cu/Zn superoxide dismutase; ACOX1, acyl-CoA oxidase 1; GOT1, cytosolic aspartate aminotransferase. Some graphics in this figure were obtained and modified from Servier Medical Art from Servier (http://www.servier.com/Powerpoint-image-bank).
See this image and copyright information in PMC

Comment on

  • Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
    Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Hu T, et al. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. Gastroenterology. 2021. PMID: 34245764 Free PMC article.

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