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Review
. 2021 Dec:71:101-109.
doi: 10.1016/j.sbi.2021.06.005. Epub 2021 Jul 16.

Enhancers navigate the three-dimensional genome to direct cell fate decisions

Juhyun Kim  1 , Ann Dean  2
Affiliations
Review

Enhancers navigate the three-dimensional genome to direct cell fate decisions

Juhyun Kim et al. Curr Opin Struct Biol. 2021 Dec.

Abstract

The activity and selectivity of transcriptional enhancers determine gene expression patterns that enable a zygote to become a complex organism. How enhancers convey regulatory information is a central conundrum in biology. Here, we discuss recent progress provided by rapidly evolving technologies in understanding enhancer-promoter interactions in the context of overall nuclear genome organization.

Keywords: Chromatin looping; Enhancer RNAs; Enhancer-promoter interractions,; Genome organization; Transcription activation.

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Conflict of interest statement

Conflict of interest statement Nothing declared.

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