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. 2023 Mar 1;40(3):263-268.
doi: 10.1097/WNP.0000000000000881. Epub 2021 Jul 6.

Oscillatory EEG-TMS Reactivity in Parkinson Disease

Emanuela Formaggio  1 , Michele Tonellato  1 , Angelo Antonini  2   3 , Leonora Castiglia  1 , Laura Gallo  1 , Paolo Manganotti  4 , Stefano Masiero  1   3 , Alessandra Del Felice  1   3
Affiliations

Oscillatory EEG-TMS Reactivity in Parkinson Disease

Emanuela Formaggio et al. J Clin Neurophysiol. .

Abstract

Purpose: A dysfunction of beta oscillatory activity is the neurophysiological hallmark of Parkinson disease (PD). How cortical activity reacts to external perturbations may provide insight into pathophysiological mechanisms. This study aims at identifying modifications in EEG rhythms after transcranial magnetic stimulation (TMS) in PD. We hypothesize that single-pulse TMS can modulate brain intrinsic oscillatory properties (e.g., beta excess).

Methods: EEG data were coregistered during single-pulse TMS (100 stimuli over the primary motor cortex [M1, hotspot for Abductor Pollicis Brevis], random intertrial interval from 8 to 13 seconds). We used a time-frequency analysis based on wavelet method to characterize modification of oscillatory rhythms (delta [1-4 Hz], theta [4-7 Hz], alpha [8-12 Hz], and beta [13-30 Hz] in 15 participants with PD compared with 10 healthy controls.

Results: An increase in beta power over the sensorimotor areas was recorded at rest in the PD group ( P < 0.05). Brain oscillations in PD transiently reset after TMS: beta power over M1 becomes comparable to that recorded in aged-matched healthy subjects in the 2 seconds following TMS.

Conclusions: Transcranial magnetic stimulation over the dominant motor cortex transiently normalizes cortical oscillations. More user-friendly noninvasive brain stimulation needs to be trialed, based on this proof of concept, to provide practical, portable techniques to treat motor symptoms in PD.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

    1. Bronte-Stewart H, Barberini C, Koop MM, Hill BC, Henderson JM, Wingeier B. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp Neurol 2008;215:20–28.
    1. Tinkhauser G, Torrecillos F, Duclos Y, et al. Beta burst coupling across the motor circuit in Parkinson's disease. Neurobiol Dis 2018;117:217–225.
    1. Fasano A, Piano C, De Simone C, et al. High frequency extradural motor cortex stimulation transiently improves axial symptoms in a patient with Parkinson's disease. Mov Disord 2008;23:1916–1919.
    1. Cilia R, Landi A, Vergani F, Sganzerla E, Pezzoli G, Antonini A. Extradural motor cortex stimulation in Parkinson's disease. Mov Disord 2007;22:111–114.
    1. Cilia R, Marotta G, Landi A, et al. Cerebral activity modulation by extradural motor cortex stimulation in Parkinson's disease: a perfusion SPECT study. Eur J Neurol 2008;15:22–28.