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. 2021 Jul 2;18(13):7078.
doi: 10.3390/ijerph18137078.

A Childhood Farm Environment Protects from Allergic Sensitization until Middle Age but Not from New-Onset Sensitization in Adulthood: A 15 Year Longitudinal Study

Anna Karoliina Haarala  1 , Suvi-Päivikki Sinikumpu  1 , Eeva Vaaramo  2 , Jari Jokelainen  2 , Markku Timonen  3 , Juha Auvinen  3   4 , Juha Pekkanen  5   6 , Laura Huilaja  1
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A Childhood Farm Environment Protects from Allergic Sensitization until Middle Age but Not from New-Onset Sensitization in Adulthood: A 15 Year Longitudinal Study

Anna Karoliina Haarala et al. Int J Environ Res Public Health. .

Abstract

Data are insufficient on the protective effect of a farm environment in childhood regarding sensitization in middle age and new-onset sensitization in adulthood. A skin prick test (SPT) and questionnaire data from the Northern Finland Birth Cohort 1966 study (NFBC66) were used to investigate sensitization at age 46 years related to childhood living environment. A subpopulation of 3409 participants was analyzed to study factors related to new-onset sensitization between ages of 31 and 46 years. Data on complete SPTs were available for 5373 cohort members at age 46. Professional farming by parents (odds ratio (OR) 0.54; 95% confidence interval (CI) 0.43-0.68) and keeping of farm animals (OR 0.53; 95% CI 0.43-0.66) in infancy were associated with a lower risk of sensitization at age 46. Sensitization (OR 0.58; 95% CI 0.47-0.72) and polysensitization (OR 0.43; 95% CI 0.32-0.57) were less common in those who lived in a rural area in infancy compared to a city area. The childhood living environment had no effect on new-onset sensitization between ages 31 and 46. We conclude that living on a farm or in a rural environment in childhood had a protective effect on sensitization even in middle age, but these factors did not protect from new-onset sensitization in adults.

Keywords: adulthood; childhood; farm; new onset; sensitization.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Flow chart of the NFBC 1966 population: follow-up visits including skin prick tests (SPTs).
See this image and copyright information in PMC

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References

    1. Pawankar R. Allergic diseases and asthma: A global public health concern and a call to action. World Allergy Organ. J. 2014;7:1–12. doi: 10.1186/1939-4551-7-12. - DOI - PMC - PubMed
    1. Leth-Møller K.B., Skaaby T., Linneberg A. Allergic rhinitis and allergic sensitisation are still increasing among Danish adults. Allergy. 2020;75:660–668. doi: 10.1111/all.14046. - DOI - PubMed
    1. Haarala A.K., Sinikumpu S.-P., Vaaramo E., Jokelainen J., Timonen M., Auvinen J., Pekkanen J., Lampi J., Huilaja L. Incidence and remission of aeroallergen sensitization in adults in Northern Finland: 15 years longitudinal study. Sci. Rep. 2021;11:4249. doi: 10.1038/s41598-021-83326-6. - DOI - PMC - PubMed
    1. Yabuhara A., Macaubas C., Prescott S.L., Venaille T.J., Holt B.J., Habre W., Sly P., Holt P.G. TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin. Exp. Allergy. 1997;27:1261–1269. doi: 10.1111/j.1365-2222.1997.tb01170.x. - DOI - PubMed
    1. Reynolds L., Finlay B.B. Early life factors that affect allergy development. Nat. Rev. Immunol. 2017;17:518–528. doi: 10.1038/nri.2017.39. - DOI - PubMed

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