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. 2023 Jul;40(9):953-959.
doi: 10.1055/s-0041-1732451. Epub 2021 Jul 19.

Assisted Reproductive Technology and Perinatal Mortality: Selected States (2006-2011)

Jeani Chang  1 , Yujia Zhang  1 , Sheree L Boulet  2 , Sara B Crawford  1 , Glenn E Copeland  3 , Dana Bernson  4 , Russell S Kirby  5 , Dmitry M Kissin  1 , Wanda D Barfield  1 ; for States Monitoring Assisted Reproductive Technology (SMART) Collaborative
Affiliations

Assisted Reproductive Technology and Perinatal Mortality: Selected States (2006-2011)

Jeani Chang et al. Am J Perinatol. 2023 Jul.

Abstract

Objective: This study aimed to compare trends and characteristics of assisted reproductive technology (ART) and non-ART perinatal deaths and to evaluate the association of perinatal mortality and method of conception (ART vs. non-ART) among ART and non-ART deliveries in Florida, Massachusetts, and Michigan from 2006 to 2011.

Study design: Retrospective cohort study using linked ART surveillance and vital records data from Florida, Massachusetts, and Michigan.

Results: During 2006 to 2011, a total of 570 ART-conceived perinatal deaths and 25,158 non-ART conceived perinatal deaths were identified from the participating states. Overall, ART perinatal mortality rates were lower than non-ART perinatal mortality rates for both singletons (7.0/1,000 births vs. 10.2/1,000 births) and multiples (22.8/1,000 births vs. 41.2/1,000 births). At <28 weeks of gestation, the risk of perinatal death among ART singletons was significantly lower than non-ART singletons (adjusted risk ratio [aRR] = 0.46, 95% confidence interval [CI]: 0.26-0.85). Similar results were observed among multiples at <28 weeks of gestation (aRR = 0.64, 95% CI: 0.45-0.89).

Conclusion: Our findings suggest that ART use is associated with a decreased risk of perinatal deaths prior to 28 weeks of gestation, which may be explained by earlier detection and management of fetal and maternal conditions among ART-conceived pregnancies. These findings provide valuable information for health care providers, including infertility specialists, obstetricians, and pediatricians when counseling ART users on risk of treatment.

Key points: · ART use is associated with a decreased risk of perinatal deaths prior to 28 weeks of gestation.. · ART perinatal mortality rates were lower than that for non-ART perinatal mortality.. · This study used linked data to examine associations between use of ART and perinatal deaths..

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Assisted reproductive technology and nonassisted reproductive technology perinatal mortality rates by plurality and year.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. 2017 National Survey of Family Growth. Accessed 2021 at: https://www.cdc.gov/nchs/nsfg/key_statistics/i.html
    1. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2016 Assisted Reproductive Technology National Summary Report. Atlanta (GA): U.S. Dept of Health and Human Services. 2018
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    1. MacDorman MF, Kirmeyer SE, Wilson EC. Fetal and perinatal mortality,UnitedStates,2006.NatlVitalStat Rep 2012;60(08):1–22 - PubMed
    1. Kawwass JF, Kissin DM, Kulkarni AD, et al.; National ART Surveillance System (NASS) Group. Safety of assisted reproductive technology in the United States, 2000–2011. JAMA 2015;313(01):88–90 - PubMed

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