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Clinical Trial
. 2022 Feb 1;49(2):e38-e41.
doi: 10.1097/OLQ.0000000000001515.

Chlorhexidine Mouthwash Fails to Eradicate Oropharyngeal Gonorrhea in a Clinical Pilot Trial (MoNg)

Christophe Van Dijck, Achilleas Tsoumanis  1 , Annelies De Hondt  1 , Vicky Cuylaerts  1 , Jolein Laumen, Yven Van Herrewege  1 , Eric Florence  1 , Irith De Baetselier  1 , Chris Kenyon
Affiliations
Clinical Trial

Chlorhexidine Mouthwash Fails to Eradicate Oropharyngeal Gonorrhea in a Clinical Pilot Trial (MoNg)

Christophe Van Dijck et al. Sex Transm Dis. .

Abstract

This single-arm open-label pilot trial in Antwerp, Belgium, was ended early in accordance with the protocol because twice-daily gargling with chlorhexidine 0.2% for 6 days failed to eradicate Neisseria gonorrhoeae from the oropharynx of asymptomatic men who have sex with men (n = 3; efficacy of 0%; 95% confidence interval, 0%-56.1%).

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Conflict of interest statement

Conflict of Interest and Sources of Funding: This trial was funded by an internal departmental grant. No conflicts of interest were declared.

References

    1. Miari VF, Ison CA. Is there a role for topical antiseptics in the treatment of gonorrhoea? Sex Transm Infect 2017; 93:79–80.
    1. Kong FYS, Horner P, Unemo M, et al. Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: A review. J Antimicrob Chemother 2019; 74:1157–1166.
    1. Kong FYS, Hatzis CL, Lau A, et al. Treatment efficacy for pharyngeal Neisseria gonorrhoeae : A systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2020; 75:3109–3119.
    1. Van Dijck C, Tsoumanis A, Rotsaert A, et al. Antibacterial mouthwash to prevent sexually transmitted infections in men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): A randomised, placebo-controlled, crossover trial. Lancet Infect Dis 2021; 21:657–667.
    1. Chow EPF, Maddaford K, Hocking JS, et al. An open-label, parallel-group, randomised controlled trial of antiseptic mouthwash versus antibiotics for oropharyngeal gonorrhoea treatment (OMEGA2). Sci Rep 2020; 10:1–7.

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