Review

. 2021 Dec;53(12):1891-1902.

doi: 10.1007/s00726-021-03032-5. Epub 2021 Jul 20.

Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

Yating Liu^{1

2

3}, Chao Mao^{2

3}, Shuang Liu⁴, Desheng Xiao^{5

6}, Ying Shi^{7

8}, Yongguang Tao^{9

10

11}

Affiliations

¹ Postdoctoral Research Station of Clinical Medicine & Department of Hematology and Critical Care Medicine, Central South University, the 3rd Xiangya Hospital, Changsha, 410000, People's Republic of China.
² Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China.
³ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China.
⁴ Department of Oncology, Institute of Medical Sciences, Center for Geriatric Disorders, National Clinical Research, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
⁵ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. xdsh96@csu.edu.cn.
⁶ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. xdsh96@csu.edu.cn.
⁷ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. yingshi@csu.edu.cn.
⁸ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. yingshi@csu.edu.cn.
⁹ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. taoyong@csu.edu.cn.
¹⁰ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. taoyong@csu.edu.cn.
¹¹ Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Second Xiangya Hospital, Central South University, Changsha, 410011, China. taoyong@csu.edu.cn.

PMID: 34283310
DOI: 10.1007/s00726-021-03032-5

Review

Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

Yating Liu et al. Amino Acids. 2021 Dec.

. 2021 Dec;53(12):1891-1902.

doi: 10.1007/s00726-021-03032-5. Epub 2021 Jul 20.

Authors

Yating Liu^{1

2

3}, Chao Mao^{2

3}, Shuang Liu⁴, Desheng Xiao^{5

6}, Ying Shi^{7

8}, Yongguang Tao^{9

10

11}

Affiliations

¹ Postdoctoral Research Station of Clinical Medicine & Department of Hematology and Critical Care Medicine, Central South University, the 3rd Xiangya Hospital, Changsha, 410000, People's Republic of China.
² Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China.
³ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China.
⁴ Department of Oncology, Institute of Medical Sciences, Center for Geriatric Disorders, National Clinical Research, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
⁵ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. xdsh96@csu.edu.cn.
⁶ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. xdsh96@csu.edu.cn.
⁷ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. yingshi@csu.edu.cn.
⁸ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. yingshi@csu.edu.cn.
⁹ Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. taoyong@csu.edu.cn.
¹⁰ NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China. taoyong@csu.edu.cn.
¹¹ Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Second Xiangya Hospital, Central South University, Changsha, 410011, China. taoyong@csu.edu.cn.

PMID: 34283310
DOI: 10.1007/s00726-021-03032-5

Abstract

L-proline catabolism is emerging as a key pathway that is critical to cellular metabolism, growth, survival, and death. Proline dehydrogenase (PRODH) enzyme, which catalyzes the first step of proline catabolism, has diverse functional roles in regulating many pathophysiological processes, including apoptosis, autophagy, cell senescence, and cancer metastasis. Notably, accumulated evidence demonstrated that PRODH plays complex role in many types of cancers. In this review, we briefly introduce the function of PRODH, then its expression in different types of cancer. We next discuss the regulation of PRODH in cancer, the downstream pathways of PRODH and the therapies that are under investigation. Finally, we propose novel insights for future perspectives on the modulation of PRODH.

Keywords: Apoptosis; Autophagy; Cancer; L-proline; PRODH; p53.

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Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

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