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Review
. 2021 Oct;29(5):1307-1315.
doi: 10.1007/s10787-021-00846-3. Epub 2021 Jul 20.

Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target

Ehsan Nourbakhsh  1 , Ali Mohammadi  2 , Mohammad Salemizadeh Parizi  3 , Atena Mansouri  4 , Farnoosh Ebrahimzadeh  5
Affiliations
Review

Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target

Ehsan Nourbakhsh et al. Inflammopharmacology. 2021 Oct.

Abstract

Myeloid suppressor cells (MDSCs) are an important class of immune-regulating cells that can suppress T cell function. Most of our knowledge about the function of MDSC comes from studies of cancer models. Recent studies, however, have greatly contributed to the description of MDSC involvement in autoimmune diseases. They are known as a cell population that may negatively affect immune responses by regulating the function of CD4+ and CD8+ cells, which makes them an attractive target for autoimmune diseases therapy. However, many questions about MDSC activation, differentiation, and inhibitory functions remain unanswered. In this study, we have summarized the role of MDSCs in various autoimmune diseases, and the potential of targeting them for therapeutic benefits has been discussed.

Keywords: Autoimmunity; Diabetes; MDSC; Rheumatoid arthritis; multiple sclerosis.

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