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. 2021 Nov 3;65(4):421-427.
doi: 10.20945/2359-3997000000388. Epub 2021 Jul 16.

Effect of beinaglutide treatment on weight loss in Chinese patients with type 2 diabetes mellitus and overweight/obesity

Guiying Wang  1 , Peng Wu  2 , Yan Qiu  2 , Xin Dong  2 , Yingbin Wang  1 , Yanjun Chi  1 , Fengjuan Zhang  1 , Yinyu Li  1 , Jimin Zhang  1 , Zhengli Huang  1 , Xifeng Du  2 , Zhiqiang Du  3
Affiliations

Effect of beinaglutide treatment on weight loss in Chinese patients with type 2 diabetes mellitus and overweight/obesity

Guiying Wang et al. Arch Endocrinol Metab. .

Abstract

Objective: To evaluate the effect of beinaglutide on weight loss and plasma protein patterns of inflammation/obesity relevant cytokines and biomarkers.

Methods: This study involved 36 adult patients with a body mass index (BMI) of ≥ 24 kg/m2 and T2DM. Beinaglutide was administered for three months. Changes in body weight, fasting plasma glucose (FPG) level, 2 h postprandial plasma glucose (2h-PG) level, glycosylated hemoglobin (HbA1c) level, BMI and visceral and subcutaneous fat areas were measured at baseline and after three months of treatment. In addition, relevant inflammation/obesity cytokines and biomarkers were measured.

Results: After three months, beinaglutide treatment led to significant changes, including in body weight, BMI, FPG level, HbA1c level, visceral and subcutaneous fat areas. In addition, serpin E1, leptin, C-reaction protein (CRP) and tumor necrosis factor-α (TNF-α) also decreased significantly. The plasma protein concentrations of CRP (Log2 transformed) were found to be positively correlated with the percentage of weight loss (R = 0.514 and p-value = 0.021).

Conclusion: Beinaglutide treatment resulted in weight loss, plasma glucose control and anti-inflammatory effects in patients with T2DM and overweight/obesity.

Keywords: GLP-1; T2DM; obesity; overweight.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Comparison of baseline and treatment of patients receiving beinaglutide in body weight (A), body mass index (B), waist circumference (C), hip circumference (D), waist/hip rate (E), visceral fat area (F), subcutaneous fat area (G), HbA1c (H), fasting plasma glucose (I), heart rate (J), systolic blood pressure (K) and diastolic blood pressure (L). * p < 0.05; **p < 0.01; ***p < 0.001.
Figure 2
Figure 2. Comparison of baseline and treatment of patients receiving beinaglutide in 4 inflammation/obesity related cytokines/biomarkers. (A) Serpin E1, (B) TNF-α, (C) Leptin, (D) C-reactive protein. * p < 0.05; **p < 0.01; ***p < 0.001.
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