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Comment
. 2021 Dec;75(6):1506-1509.
doi: 10.1016/j.jhep.2021.07.012. Epub 2021 Jul 17.

SARS-CoV-2-specific immunity in immunosuppressed COVID-19 convalescents with autoimmune hepatitis

Theresa Kirchner  1 , Elmar Jaeckel  1 , Christine S Falk  2 , Britta Eiz-Vesper  3 , Richard Taubert  4
Affiliations
Comment

SARS-CoV-2-specific immunity in immunosuppressed COVID-19 convalescents with autoimmune hepatitis

Theresa Kirchner et al. J Hepatol. 2021 Dec.
No abstract available

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Conflict of interest statement

Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
SARS-CoV-2-specific immunity in immunosuppressed COVID-19 convalescence with autoimmune hepatitis. (A) IgM, IgA and IgG with reactivity against various SARS-CoV-2 antigens (spike protein, RBD, N) were measured in COVID-19 convalescents with AIH and in a local cohort of non-immunosuppressed convalescents (non-IS) (∗p <0.05 in Fisher’s exact test compared to IS-Con). (B) Concentration of anti-SARS-CoV-2 antibodies (measured as MFI) in AIH and non-IS convalescents. Non-significant differences in Mann-Whitney U tests were not outlined. (C) Anti-SARS-CoV-2 antibody concentrations measured longitudinally before and after COVID-19 in 2 patients with AIH with available pre-pandemic blood samples. (D) IFN-γ production upon stimulation with various SARS-CoV-2 antigen sets in ELISPOT assays normalized to numbers of circulating PBMCs as well as CD3+ T cells in immunosuppressed COVID-19 convalescents with AIH and non-IS. Non-significant differences in Mann-Whitney U tests were not outlined. AIH, autoimmune hepatitis; non-IS, non-immunosuppressed convalescents; MFI median fluorescence intensity; N, nucleocapsid; PBMCs, peripheral blood mononuclear cell; RBD, receptor binding domain.
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 infection in patients with autoimmune hepatitis.
    Marjot T, Buescher G, Sebode M, Barnes E, Barritt AS 4th, Armstrong MJ, Baldelli L, Kennedy J, Mercer C, Ozga AK, Casar C, Schramm C; contributing Members and Collaborators of ERN RARE-LIVER/COVID-Hep/SECURE-Cirrhosis; Moon AM, Webb GJ, Lohse AW. Marjot T, et al. J Hepatol. 2021 Jun;74(6):1335-1343. doi: 10.1016/j.jhep.2021.01.021. Epub 2021 Jan 26. J Hepatol. 2021. PMID: 33508378 Free PMC article.

References

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