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. 2021 Jul 20;31(3):9906.
doi: 10.4081/ejtm.2021.9906.

Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series

Francesca Cantele  1 , Lucrezia Tognolo  2 , Francesca Caneva  3 , Emanuela Formaggio  4 , Valentina Copetti  5 , Andrea Venturin  6 , Allegra Caregnato  7 , Stefano Masiero  8
Affiliations

Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series

Francesca Cantele et al. Eur J Transl Myol. .

Abstract

The aim of the study was to identify the variables related to therapeutic success of intramuscular oxygen-ozone (O2O3) in patients with chronic low back pain (LBP). Twenty-one patients underwent an eight-session intramuscular-paravertebral O2O3 treatment with a weekly frequency. Numeric Rating Score for pain (NRSp), anxiety (NRSa), mood (NRSm), Oswestry Disability Index (ODI) and Physical and Mental Component Summary scores (PCS and MCS) of Short Form 12 (SF-12) were assessed baseline, after the treatment and at six-months follow-up. The ODI and NRSp scores showed significant improvement at the end of the treatment: the improvement in pain was maintained also at 6 months' follow-up. A significant correlation between baseline NRSa and the variation of the NRSp and ODI was observed. There was a correlation between NRSm at baseline and the variation of the ODI. A moderate correlation between MCS-12 at baseline and the variation of the NRSp score was found. Surprisingly, patients with a more compromised psychological well-being due to LBP had better results after oxygen-ozone therapy. Therefore, NRSa, NRSm and MCS-12 scores could be useful predictors of good therapeutic outcome.

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Conflict of interest statement

We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

Fig 1.
Fig 1.
NRSp, NRSa and NRSm scores at T0, T1 and T2. On each box, the central red line indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers, and the outliers are plotted individually using the ’+’ symbol.
Fig 2.
Fig 2.
Pearson correlation between NRSa at T0 and the differences (T1-T0) of NRSp (ΔNRSp) (correlation coefficient r = -0.48, p = 0.03) (a); between NRSa at T0 and ΔODI (r = -0.55, p = 0.015) (b); between NRSm at T0 and ΔNRSp (r = 0.6, p = 0.009) (c); between MCS-12 and ΔNRSp (r = 0.51, p = 0.022) (d); between MCS-12 and ΔODI (r = 0.45, p = 0.055) (e).
See this image and copyright information in PMC

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