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Randomized Controlled Trial
. 2021 Jul 20;21(1):433.
doi: 10.1186/s12877-021-02374-9.

Effect of 12-weeks elastic band resistance training on MyomiRs and osteoporosis markers in elderly women with Osteosarcopenic obesity: a randomized controlled trial

Ebrahim Banitalebi  1 , Majid Mardaniyan Ghahfarrokhi  1 , Mortaza Dehghan  2
Affiliations
Randomized Controlled Trial

Effect of 12-weeks elastic band resistance training on MyomiRs and osteoporosis markers in elderly women with Osteosarcopenic obesity: a randomized controlled trial

Ebrahim Banitalebi et al. BMC Geriatr. .

Abstract

Background: Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX® score in elderly women with osteosarcopenic obesity (OSO).

Methods: In this randomized controlled trial, 63 women (aged 65-80 years) with Osteosarcopenic Obesity were recruited and assessed, using a dual-energy X-ray absorptiometry instrument. The resistance-type training via elastic bands was further designed three times per week for 12-weeks. The main outcomes were Fracture Risk Assessment Tool score, bone mineral content, bone mineral density, vitamin D, alkaline phosphatase, C-terminal telopeptides of type I collagen, expression of miR-206 and miR-133.

Results: There was no significant difference between the study groups in terms of the Fracture Risk Assessment Tool score (p = 0.067), vitamin D (p = 0.566), alkaline phosphatase (p = 0.334), C-terminal telopeptides of type I collagen (p = 0.067), microR-133 (p = 0.093) and miR-206 (p = 0.723).

Conclusion: Overall, the results of this study illustrated 12-weeks of elastic band resistance training causes a slight and insignificant improvement in osteoporosis markers in women affected with Osteosarcopenic Obesity.

Trial registration: Randomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20180627040260N1 . Date of registration: 27/11/2018.

Keywords: MyomiRs; Osteoporosis markers; Osteosarcopenic obesity; Resistance training.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram representing study design
Fig. 2
Fig. 2
Osteoporosis markers change following 12 weeks of elastic band resistance training. BMD: bone mass density; BMC: body mass content; FRAX: fracture risk assessment tool; CTX-I: C-telopeptides of type I collagen. # indicates a significant difference at P < 0.05
Fig. 3
Fig. 3
myoMirs (miR-133 and miR-206) following 12 weeks of elastic band resistance training
Fig. 4
Fig. 4
Bivariate correlation between myoMirs (miR-133 and miR-206) and osteoporosis markers (BMC, BMD, FRAX, vitamin D, alkaline phosphatase, and CTX-I) following elastic-band resistance training. BMD: bone mass density; BMC: bone mass content; FRAX: Fracture Risk Assessment Tool; CTX-I: C-telopeptides of type I collagen; miR-133: MicroRNA-133; miR-206: MicroRNA-206. * and ** indicates significant correlation at P < 0.05 and P < 0.01 respectively
See this image and copyright information in PMC

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