doi: 10.1016/0020-711x(87)90307-7.
Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1
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- PMID: 3428478
- DOI: 10.1016/0020-711x(87)90307-7
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Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1
Int J Biochem.
1987.
Abstract
1. Reduction of vitamin K1 2,3-epoxide by rat and human liver vitamin K epoxide reductase is inhibited by N-ethylmaleimide and iodoacetamide. 2. Both enzymes are protected from inhibition by N-ethylmaleimide by vitamin K1 or vitamin K1 2,3-epoxide. 3. Vitamin K1 inhibits reduction of vitamin K1 2,3-epoxide to vitamin K1 which suggests product inhibition of the enzyme.
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