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Case Reports
. 2021 Sep-Oct;96(5):595-597.
doi: 10.1016/j.abd.2021.01.003. Epub 2021 Jul 18.

Disseminated mucocutaneous trichosporonosis in a patient with histiocytic sarcoma

Arturo Robles-Tenorio  1 , Rossy Anahí Rivas-López  2 , Alexandro Bonifaz  3 , Víctor Manuel Tarango-Martínez  4
Affiliations
Case Reports

Disseminated mucocutaneous trichosporonosis in a patient with histiocytic sarcoma

Arturo Robles-Tenorio et al. An Bras Dermatol. 2021 Sep-Oct.

Abstract

Trichosporon asahii is the causal agent of trichosporonosis. Patients with immunosuppression or hematological malignancies are at higher risk of infection. Skin and mucosal involvement appear as fast-growing papulonodular lesions and necrotic ulcers. Internal organ dissemination is lethal. Therapeutic success depends on the underlying disease. Here, the authors present the first case of disseminated mucocutaneous trichosporonosis in a patient with a post-mortem diagnosis of histiocytic sarcoma, a rare and aggressive haematolymphoid neoplasm. Regretfully, death occurred despite treatment with liposomal amphotericin B and supportive measures, showcasing the fatality of both diseases.

Keywords: Hematologic neoplasms; Histiocytic sarcoma; Trichosporon; Trichosporonosis; Ulcer.

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Figures

Figure 1
Figure 1
Large, necrotic face ulcers affecting the cheek and the oral mucosa.
Figure 2
Figure 2
Face ulcer examinations. (A), Budding yeast cells and (B), PAS stained blastoconidia are observed on a Gram smear and on histopathology, respectively.
Figure 3
Figure 3
Face ulcer culture. (A), Trichosporon spp. colonies showed a raised, waxy appearance with radial furrows on Sabouraud culture. (B), Culture smear revealed hyphae, blastoconidia and arthroconidia with cotton blue stain.
See this image and copyright information in PMC

References

    1. Duarte-Oliveira C., Rodrigues F., Gonçalves S.M., Goldman G.H., Carvalho A., Cunha C. The Cell Biology of the Trichosporon-Host Interaction. Front Cell Infect Microbiol. 2017;7:118. - PMC - PubMed
    1. Colombo A.L., Padovan A.C.B., Chaves G.M. Current knowledge of Trichosporon spp. and Trichosporonosis. Clin Microbiol Rev. 2011;24:682–700. - PMC - PubMed
    1. Vázquez-González D., Perusquía-Ortiz A.M., Hundeiker M., Bonifaz A. Opportunistic yeast infections: candidiasis, cryptococcosis, trichosporonosis and geotrichosis. J Dtsch Dermatol Ges. 2013;11:381–394. - PubMed
    1. Arendrup M.C., Boekhout T., Akova M., Meis J.F., Cornely O.A., Lortholary O. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin Microbiol Infect. 2014;20:76–98. - PubMed
    1. de Almeida J.N., Gimenes V.M.F., Francisco E.C., Siqueira L.P.M., de Almeida R.K.G., Guitard J. Evaluating and improving Vitek MS for identification of clinically relevant species of Trichosporon and the closely related genera Cutaneotrichosporon and Apiotrichum. J Clin Microbiol. 2017;55:2439–2444. - PMC - PubMed

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