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Comment
. 2021 Jul 20;6(1):279.
doi: 10.1038/s41392-021-00693-2.

Competition for nutrients or cell intrinsic programming? - Metabolic mechanisms behind the tumor promoting immune microenvironment in cancer

Yuequn Niu  1 , Thomas Mayr  1 , Michael H Muders  2
Affiliations
Comment

Competition for nutrients or cell intrinsic programming? - Metabolic mechanisms behind the tumor promoting immune microenvironment in cancer

Yuequn Niu et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The mTORC1-driven metabolic reprogramming of distinct cell populations in TME. On the baseline level, the myeloid cells exhibit the greatest glucose uptake, followed by cancer cells and T cells in TME; while the cancer cells have the highest glutamine uptake level. All the cell populations in TME show higher nutrient uptake level than the normal splenic T cells. The inhibition of mTORC1 by rapamycin decreases the uptake of glucose and glutamine in all cell populations, and the blockade of glutamine transport induces upregulation of glucose uptake which might induce competition for glucose and reversal of immune suppression. The width of arrows, size of the cells, and the direction of the triangles represent the nutrient uptake accessibility (from high to low). The symbol “~” represents similar nutrient accessibility.
See this image and copyright information in PMC

Comment on

  • Cell-programmed nutrient partitioning in the tumour microenvironment.
    Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Reinfeld BI, et al. Nature. 2021 May;593(7858):282-288. doi: 10.1038/s41586-021-03442-1. Epub 2021 Apr 7. Nature. 2021. PMID: 33828302 Free PMC article.

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