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Review
. 2021 Jul 12:17:2309-2314.
doi: 10.2147/NDT.S322884. eCollection 2021.

Epilepsy in Older People in Sub-Saharan Africa: A Systematic Review

Felix Bongomin  1   2 , Elly Katabira  1 , Martha Sajatovic  3 , Mark Kaddumukasa  1
Affiliations
Review

Epilepsy in Older People in Sub-Saharan Africa: A Systematic Review

Felix Bongomin et al. Neuropsychiatr Dis Treat. .

Abstract

Background: Over one-fourth of new onset epilepsy occurs after age 60. However, the burden of epilepsy and other seizure disorders among this special population in Africa is largely unknown, despite a growingnumber of elderly persons on the continent. This study aimed to assess the prevalence and risk factors for epilepsy among persons aged 60 years or older in Africa.

Methods: We conducted a systematic review by searching MEDLINE (via) and EMBASE databases from inception to 30th October 2020. Primary researches reporting prevalence or incidence of seizures or epilepsy in older persons (≥60 years) were included. Review articles were excluded.

Results: We retrieved 107 citations from which 4 studies, recruiting 10, 334 participants were eligible. The studies were conducted between 1999 and 2018 and published between 2005 and 2019. Two of the studies were conducted in the West African countries of Niger and Senegal; meanwhile, the remaining 2 were conducted in East African country of Tanzania. Regarding study design, three were either hospital-based or community-based cross-sectional studies. Meanwhile, 1 was a retrospective hospital-based study. Of the 10,334 participants, 81 (0.78%) had a seizure disorder. The prevalence of seizure ranged from 0.02% to 3.2%.

Conclusion: There are limited data on the prevalence of epilepsy in older persons in older adults in most countries in sub-Saharan Africa. Epilepsy among the older adults remains a challenge in Africa and more information is needed to understand the burden to improve care.

Keywords: elderly persons; epilepsy; seizure; sub-Saharan Africa.

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Conflict of interest statement

Professor Martha Sajatovic reports grants from Nuromate, Otsuka, Alkermes, International Society for Bipolar Disorders (ISBD) and personal fees from Alkermes, Otsuka, Janssen, Myriad, Health Analytics, Frontline Medical Communications, Springer Press, Johns Hopkins University Press, Oxford Press, UpToDate, American Physician’s Institute, MCM Education, CMEology, Potomac Center for Medical Education, Global Medical Education, Creative Educational Concepts, and Psychopharmacology Institute, outside the submitted work. The authors declare that they have no other potential conflicts of interest for this work.

Figures

Figure 1
Figure 1
PRISMA flow diagram. Notes: PRISMA figure adapted from Liberati A, Altman D, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of Clinical Epidemiology. 2009;62(10)e1-e34. Creative Commons.
See this image and copyright information in PMC

References

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