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Case Reports
. 2021 Mar 29:38:314.
doi: 10.11604/pamj.2021.38.314.22410. eCollection 2021.

Diagnosis of Evans syndrome

Andreas Angelopoulos  1 , George Kirkilesis  2 , Kiriaki Kakavia  3 , Paraskevi Papanikolaou  1
Affiliations
Case Reports

Diagnosis of Evans syndrome

Andreas Angelopoulos et al. Pan Afr Med J. .

Abstract

This manuscript concerns the case of a patient hospitalized and diagnosed with Evans syndrome. She was hospitalized with signs of thrombocytopenia induced purpura, petechiae, ecchymosis and anemia. She was successfully treated with corticoids and blood transfusions. Our purpose is to explain her clinical presentation and the exams, we used in order to make the diagnosis of Evans syndrome, which requires great suspicion. Moreover, other diseases causing hemolytic anemia and thrombocytopenia must be excluded. We used laboratory tests (blood samples, Coombs examination and virologic test). Bone marrow examination took place twice. Evans syndrome is an autoimmune disease which is characterized by the coexistence of hemolytic anemia and immune-mediated thrombocytopenia. There is no typical clinical presentation. Its etiology is unknown and its therapy is generally poor. Diagnosis of Evans syndrome is very difficult and requires the exclusion of other diseases causing anemia and thrombocytopenia.

Keywords: Evans syndrome; anemia; hemolysis; thrombocytopenia.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
appearance of ecchymosis and petechiae all over the body and limbs of the patient
See this image and copyright information in PMC

References

    1. Evans RS, Takahashi K, Duane RT, Payne R, Liu C. Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology. AMA Arch Intern Med. 1951 Jan;87(1):48–65. - PubMed
    1. Porcaro F, Valenzise M, Candela G, Chiera F, Corica D, Pitrolo E, et al. Evans syndrome: a case report. Pediatr Med Chir. 2014 Aug 31;36(4):91. - PubMed
    1. Karakantza M, Mouzaki A, Theodoropoulou M, Bussel JB, Maniatis A. Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia. Br J Haematol. 2000 Sep;110(4):968–70. - PubMed
    1. Norton A, Roberts I. Management of Evans syndrome. Br J Haematol. 2006 Jan;132(2):125–37. - PubMed
    1. Blanchette VS, Kirby MA, Turner C. Role of intravenous immunoglobulin G in autoimmune hematologic disorders. Semin Hematol. 1992 Jul;29(3 Suppl 2):72–82. - PubMed

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