The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente^{1

2}, Kin Seng Liem^{2

3}, Kathleen B Schwarz^{4

5}, Philip Rosenthal⁶, Karen F Murray⁷, Douglas Mogul⁵, Jeffery Teckman⁸, Norberto Rodriguez-Baez⁹, Sarah Jane Schwarzenberg¹⁰, Jordan J Feld^{2

11}, David K Wong², Lia L Lewis-Ximenez¹², Georg Lauer¹³, Bettina E Hansen^{2

14}, Simon C Ling^{15

16}, Harry L A Janssen^{2

11}, Adam J Gehring^{1

2

11}

Affiliations

¹ Department of Immunology, University of Toronto, Ontario, Canada.
² Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
³ Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
⁴ Division of Pediatric Gastroenterology, University of California, San Diego, San Diego, California, USA.
⁵ Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
⁶ Department of Pediatrics, University of California, San Francisco , San Francisco, California, USA.
⁷ Seattle Children's Hospital, Seattle, Washington, USA.
⁸ Department of Pediatrics, Saint Louis University, St Louis, Missouri, USA.
⁹ Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA.
¹⁰ Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
¹¹ Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
¹² Viral Hepatitis Laboratory, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
¹³ Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁴ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
¹⁵ Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
¹⁶ Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

PMID: 34286845
DOI: 10.1093/infdis/jiab373

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente et al. J Infect Dis. 2022.

. 2022 Feb 1;225(3):470-475.

doi: 10.1093/infdis/jiab373.

Authors

Affiliations

¹ Department of Immunology, University of Toronto, Ontario, Canada.
² Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
³ Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
⁴ Division of Pediatric Gastroenterology, University of California, San Diego, San Diego, California, USA.
⁵ Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
⁶ Department of Pediatrics, University of California, San Francisco , San Francisco, California, USA.
⁷ Seattle Children's Hospital, Seattle, Washington, USA.
⁸ Department of Pediatrics, Saint Louis University, St Louis, Missouri, USA.
⁹ Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA.
¹⁰ Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
¹¹ Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
¹² Viral Hepatitis Laboratory, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
¹³ Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁴ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
¹⁵ Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
¹⁶ Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

PMID: 34286845
DOI: 10.1093/infdis/jiab373

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Keywords: HBV; biomarker; chemokines; cytokines; flare; hepatitis B; immune response; inflammation; plasma.

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The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

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The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

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