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. 2021 Jul 21;25(3):422-427.
doi: 10.5935/1518-0557.20210003.

Prediction of ovarian response in IVF/ICSI cycles

Alfredo Cortés-Vazquez  1 , Guillermo A Goitia-Landeros  1 , Miguel A Regalado  1 , Saúl R León-Hernández  2 , Alfredo L Cortés-Algara  1 , Cindy Bandala  3   4 , Jesús D Moreno-García  1 , Panagiotis Drakopoulos  5   6
Affiliations

Prediction of ovarian response in IVF/ICSI cycles

Alfredo Cortés-Vazquez et al. JBRA Assist Reprod. .

Abstract

Objective: Our study aims to evaluate the various correlations between demographic, biochemical, ultrasound, and ovarian stimulation parameters with the percentage of mature oocytes in conventional stimulation for IVF/ICSI cycles in order to develop a predictive model to improve our understanding of the oocyte maturation process.

Methods: This is a retrospective cohort study; patients underwent conventional antagonist ovarian stimulation protocols for fresh IVF/ICSI cycles. A total of 256 IVF/ICSI cycles were included. Age, antral follicle count (AFC), baseline serum follicle-stimulating hormone (FSH) levels, baseline serum luteinizing hormone (LH) levels, baseline serum estradiol (E2) levels, peak estradiol, P4 on hCG day, the body mass index (BMI), and stimulation length were measured. The variables were tested for correlations with the number of retrieved oocytes (#RO) and the number of mature oocytes (#MO). A backward stepwise regression was performed to identify the variables that correlated more strongly with percentage of mature oocytes (%MO).

Results: A predictive equation was obtained with the variables that were not excluded in the model. % MO = 72.700 - 0.910 (Age) + 0.979 (BMI) + 1.209 (Baseline serum LH) - 0.647 (Progesterone on human Chorionic Gonadotropin day).

Conclusions: We concluded that age, the BMI, baseline serum LH, and progesterone level on hCG day may predict %MO. Prospective studies are required to validate this predictive equation.

Keywords: Age; LH; Mature; Oocyte; body mass index; progesterone.

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Conflict of interest statement

CONFLICT OF INTEREST

None.

Figures

Figure 1
Figure 1
Correlation between number of retrieved oocyte and number of mature oocytes. #Mature oocyte= number of mature oocytes
See this image and copyright information in PMC

References

    1. Beall S, Brenner C, Segars J. Oocyte maturation failure: a syndrome of bad eggs. Fertil Steril. 2010;94:2507–2513. doi: 10.1016/j.fertnstert.2010.02.037. - DOI - PMC - PubMed
    1. Chalumeau C, Moreau J, Gatimel N, Cohade C, Lesourd F, Parinaud J, Leandri R. Establishment and validation of a score to predict ovarian response to stimulation in IVF. Reprod Biomed Online. 2018;36:26–31. doi: 10.1016/j.rbmo.2017.09.011. - DOI - PubMed
    1. Davar R, Naghshineh E, Neghab N. The effect of 24 hours delay in oocyte maturation triggering in IVF/ICSI cycles with antagonist protocol and not-elevated progesterone: A randomized control trial. Int J Reprod Biomed. 2017;15:441–446. doi: 10.29252/ijrm.15.7.441. - DOI - PMC - PubMed
    1. Dumesic DA, Meldrum DR, Katz-Jaffe MG, Krisher RL, Schoolcraft WB. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril. 2015;103:303–316. doi: 10.1016/j.fertnstert.2014.11.015. - DOI - PubMed
    1. Engmann L, Benadiva C, Humaidan P. GnRH agonist trigger for the induction of oocyte maturation in GnRH antagonist IVF cycles: a SWOT analysis. Reprod Biomed Online. 2016;32:274–285. doi: 10.1016/j.rbmo.2015.12.007. - DOI - PubMed