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Review
. 2021 Jul 5;8(3):271-276.
doi: 10.3390/dermatopathology8030033.

"Animal-Type Melanoma/Pigmented Epithelioid Melanocytoma": History and Features of a Controversial Entity

Gerardo Cazzato  1 , Francesca Arezzo  2 , Anna Colagrande  1 , Antonietta Cimmino  1 , Teresa Lettini  1 , Sara Sablone  3 , Leonardo Resta  1 , Giuseppe Ingravallo  1
Affiliations
Review

"Animal-Type Melanoma/Pigmented Epithelioid Melanocytoma": History and Features of a Controversial Entity

Gerardo Cazzato et al. Dermatopathology (Basel). .

Abstract

Animal-type melanoma (ATM) was first described in the literature by Levene in 1979 in relation to a patient with a characteristic clinical presentation, and only later, rare and anecdotal case series have tried to shed light on an entity that has undergone several nosographic classification changes, and which, since 2018, is classified under the term "pigmented epithelioid melanocytoma". Here, we conduct a brief review of the current literature on ATM and present a new clinical case with histopathological, immunophenotypic, and molecular investigations.

Keywords: animal-type; malignancies; melanoma; skin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Skin and subcutis including intensely pigmented melanocyte proliferation. (Hematoxylin-Eosin, Original Magnification: 4×). (B) Histological detail of melanocyte proliferation consisting of variously intertwined cells, with evident presence of melanic pigment. (Hematoxylin-Eosin, Original Magnification: 10×). (C) Immunohistochemical preparation with anti-Melan-A antibody which highlights the melanocyte proliferation in question (Immunohistochemistry, Original Magnification: 4×). (D) Detail of micrometastases in the sentinel lymph node (Hematoxylin-Eosin, Original Magnification: 4×).
See this image and copyright information in PMC

References

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